Introduction. Erectile dysfunction (ED) is usually associated with systemic disorders. This population-based study supports and expands on previous research. It also presents data in a Taiwanese male population where existing data on this topic remain sparse. Aim. The aim of this study is to analyze the prevalence and risk of 36 medical comorbidities in patients with ED compared with the general population. Methods. A total of 2,213 patients with ED and 11,065 matching controls were selected from the Taiwan National Health Insurance Research Dataset. We chose 22 comorbidities from the Elixhauser comorbidity index, 10 highly prevalent medical conditions in an Asian population, and four male gender-specific comorbidities for analysis. Main Outcome Measurement. Conditional logistic regression analyses conditioned on age group and monthly income were performed to investigate the risk of various comorbidities for patients with and without ED, after adjusting for the geographic region and level of urbanization of the patient's community. Results. Patients with ED were at an increased risk for multiple systemic comorbidities. Conditional regression analyses showed that patients with ED were at a higher risk for hypertrophy of the prostate (odds ratio [OR]=12.87), chronic prostatitis (OR=9.36), alcohol abuse (OR=3.60), drug abuse (OR=2.62), urinary incontinence (OR=2.58), ankylosing spondylitis (OR=2.19), peripheral vascular disorder (OR=1.98), ischemic heart disease (OR=1.94), psychoses (OR=1.97), depression (OR=1.88), uncomplicated diabetes (OR=1.91), complicated diabetes (OR=1.84), hepatitis B or C (OR=1.71), hyperlipidemia (OR=1.69), and chronic pulmonary disease (OR=1.55) than patients without ED. Conclusion. The results show that patients with ED have a higher prevalence of multiple noncardiovascular comorbidities than the general population in Taiwan.
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