Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

Ruo Kai Lin, Chen Yen Choong, Wei Hsuan Hsu, Chen Jei Tai, Cheng Jeng Tai

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.
原文英語
頁(從 - 到)2156-2163
頁數8
期刊African Health Sciences
19
發行號2
DOIs
出版狀態已發佈 - 六月 2019

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy」主題。共同形成了獨特的指紋。

  • 引用此