Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni

Yu Jen Chen, Po Ching Cheng, Ching Nan Lin, Hui Fen Liao, Yu Yawn Chen, Chin Chu Chen, Kin Mu Lee

研究成果: 雜誌貢獻文章

41 引文 斯高帕斯(Scopus)

摘要

Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evaluating cytokine expression; on immunomodulation, by evaluating spleen cells; and on Schistosoma mansoni infection in mice. The induction of high levels of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) mRNA was detected in BALB/c mice after 2, 4, and 6 weeks of oral AC-PS administration. After 6 weeks of oral AC-PS administration to the BALB/c mice, the number of splenic dendritic cells, macrophages, and the surface expression of CD8α+ and major histocompatibility class II I-A/I-E on dendritic cells increased. The CD4+/CD8+ ratio and number of B cells among splenocytes were also augmented. By using a disease model of parasitic infection, we found that AC-PS treatment inhibited S. mansoni infection in BALB/c mice. AC-PS appears to modulate the immune system of mice and has potential for preventing S. mansoni infection.

原文英語
頁(從 - 到)458-467
頁數10
期刊International Immunopharmacology
8
發行號3
DOIs
出版狀態已發佈 - 三月 2008
對外發佈Yes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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