Polyploidy in malignant melanoma

J. Whang‐Peng, P. Chretien, T. Knutsen

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

Chromosome studies were performed on primary or metastatic malignant melanoma from 6 patients. All of them were aneuploid and had either hyperdiploid, near triploid, tetraploid, or hypertetraploid cell lines. Two of them had definite stem‐cell lines, but the other 4 cases had a wide distribution of chromosome numbers with no apparent cell lines. Three of the 6 patients had one or more marker chromosomes, i.e., large submetacentrics or long acrocentrics. These results lead us to speculate that the rapid cell growth is due not only to selection but also to continuous replication defects and mitotic abnormalities.
原文英語
頁(從 - 到)1216-1223
頁數8
期刊Cancer
25
發行號5
DOIs
出版狀態已發佈 - 一月 1 1970
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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