Polypharmacy correlates with increased risk for hip fracture in the elderly: A population-based study

Shih Wei Lai, Kuan Fu Liao, Chien-Chang Liao, Chih Hsin Muo, Chiu Shong Liu, Fung Chang Sung

研究成果: 雜誌貢獻文章

186 引文 (Scopus)

摘要

Few studies have addressed the association between polypharmacy and hip fracture using population data. We conducted a population-based case-control study to investigate whether polypharmacy increases the risk for hip fracture in the elderly. We used insurance claims data from the Taiwan Bureau of National Health Insurance, a universal insurance program with a coverage rate of more than 98% of the population in Taiwan. We identified 2328 elderly patients with newly diagnosed hip fracture during the period 2005-2007. We randomly selected 9312 individuals without hip fracture to serve as the control group. Patient characteristics, drugs prescribed by physicians, and all types of hip fracture were ascertained. The odds ratio (OR) of hip fracture in association with the number of medications used per day in previous years was assessed.We found that patients were older than controls, predominantly female, and more likely to use 5 or more drugs (22.2% vs. 9.3%, p <0.0001). The OR of hip fracture increased with the number of medications used per day and with age. Multivariate logistic regression analysis revealed that the overall OR for patients using 10 or more drugs was 8.42 (95% confidence interval [CI], 4.73-15.0) compared with patients who used 0-1 drug per day. However, age-specific analysis revealed that the risk for hip fracture was 23 times greater for patients aged ĝ‰¥85 years who used 10 or more drugs than for those aged 65-74 years who used 0-1 drug after controlling for covariates (OR, 23.0; 95% CI, 3.77-140).We conclude that the risk of hip fracture in older people increases with the number of medications used, especially in women. Age interacts with the daily medications for the risk of hip fracture.

原文英語
頁(從 - 到)295-299
頁數5
期刊Medicine (United States)
89
發行號5
DOIs
出版狀態已發佈 - 2010
對外發佈Yes

指紋

Polypharmacy
Hip Fractures
Population
Odds Ratio
Pharmaceutical Preparations
Insurance
Taiwan
Confidence Intervals
National Health Programs
Case-Control Studies
Logistic Models
Regression Analysis
Physicians

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Polypharmacy correlates with increased risk for hip fracture in the elderly : A population-based study. / Lai, Shih Wei; Liao, Kuan Fu; Liao, Chien-Chang; Muo, Chih Hsin; Liu, Chiu Shong; Sung, Fung Chang.

於: Medicine (United States), 卷 89, 編號 5, 2010, p. 295-299.

研究成果: 雜誌貢獻文章

Lai, Shih Wei ; Liao, Kuan Fu ; Liao, Chien-Chang ; Muo, Chih Hsin ; Liu, Chiu Shong ; Sung, Fung Chang. / Polypharmacy correlates with increased risk for hip fracture in the elderly : A population-based study. 於: Medicine (United States). 2010 ; 卷 89, 編號 5. 頁 295-299.
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abstract = "Few studies have addressed the association between polypharmacy and hip fracture using population data. We conducted a population-based case-control study to investigate whether polypharmacy increases the risk for hip fracture in the elderly. We used insurance claims data from the Taiwan Bureau of National Health Insurance, a universal insurance program with a coverage rate of more than 98{\%} of the population in Taiwan. We identified 2328 elderly patients with newly diagnosed hip fracture during the period 2005-2007. We randomly selected 9312 individuals without hip fracture to serve as the control group. Patient characteristics, drugs prescribed by physicians, and all types of hip fracture were ascertained. The odds ratio (OR) of hip fracture in association with the number of medications used per day in previous years was assessed.We found that patients were older than controls, predominantly female, and more likely to use 5 or more drugs (22.2{\%} vs. 9.3{\%}, p <0.0001). The OR of hip fracture increased with the number of medications used per day and with age. Multivariate logistic regression analysis revealed that the overall OR for patients using 10 or more drugs was 8.42 (95{\%} confidence interval [CI], 4.73-15.0) compared with patients who used 0-1 drug per day. However, age-specific analysis revealed that the risk for hip fracture was 23 times greater for patients aged ĝ‰¥85 years who used 10 or more drugs than for those aged 65-74 years who used 0-1 drug after controlling for covariates (OR, 23.0; 95{\%} CI, 3.77-140).We conclude that the risk of hip fracture in older people increases with the number of medications used, especially in women. Age interacts with the daily medications for the risk of hip fracture.",
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