Polymyositis complicating donor lymphocyte infusion after stem cell transplantation for relapsed chronic myeloid leukemia: Report of a case and review of literature

Feng Cheng Liu, Chen Hung Chen, Tsu Yi Chao

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyositis. We report in this study a 25-year-old man who suffered from a relapse of CML 4 years after a sibling human leukocyte antigen-matched allogenic BMT. The patient developed polymyositis 18 months after DLI. Mini-pulse therapy with methylprednisolone was effective for his proximal weakness and elevated creatine phosphokinase. There was no relapse of symptoms of polymyositis on tapering of the medication.

原文英語
頁(從 - 到)1207-1210
頁數4
期刊Clinical Rheumatology
26
發行號7
DOIs
出版狀態已發佈 - 七月 2007
對外發佈Yes

指紋

Polymyositis
Stem Cell Transplantation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tissue Donors
Lymphocytes
Homologous Transplantation
Bone Marrow Transplantation
Recurrence
Methylprednisolone
Graft vs Host Disease
Creatine Kinase
HLA Antigens
Siblings
Therapeutics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

引用此文

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abstract = "Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyositis. We report in this study a 25-year-old man who suffered from a relapse of CML 4 years after a sibling human leukocyte antigen-matched allogenic BMT. The patient developed polymyositis 18 months after DLI. Mini-pulse therapy with methylprednisolone was effective for his proximal weakness and elevated creatine phosphokinase. There was no relapse of symptoms of polymyositis on tapering of the medication.",
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AU - Chao, Tsu Yi

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