Polymorphisms of transforming growth factor-Β signaling pathway and Kawasaki disease in the Taiwanese population

Ho Chang Kuo, Yoshihiro Onouchi, Yu Wen Hsu, Wei Chiao Chen, Jin Ding Huang, Ying Hsien Huang, Ya Ling Yang, Mei Chyn Chao, Hong Ren Yu, Yung Shun Juan, Chiu Ming Kuo, Kuender D. Yang, Jung San Huang, Wei Chiao Chang

研究成果: 雜誌貢獻文章同行評審

32 引文 斯高帕斯(Scopus)

摘要

Kawasaki disease (KD) is a systemic vasculitis associated with cardiovascular symptom. A previous study in the European descent has indicated that genetic variants of the transforming growth factor-Β (TGF-Β) pathway are involved in the KD susceptibility and clinical status. This study was conducted to investigate if polymorphisms in TGF-Β signaling pathway are associated with KD susceptibility, and the coronary artery lesion formation. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 12 single-nucleotide polymorphisms in the TGF-Β signaling pathway (rs2796817, rs10482751, rs2027567, rs12029576, rs11466480, rs4776338, rs12901071, rs7162912, rs1438386, rs6494633, rs12910698 and rs4776339) by using TaqMan Allelic Discrimination assay. Our results indicated that rs1438386 in the SMAD3 is significantly associated with the susceptibility of KD. Additionally, both haplotypes of TGFΒ2 and SMAD3 were also associated with the risk of KD. This study showed that genetic polymorphisms in TGF-Β signaling pathway are associated with KD susceptibility, but not coronary artery lesions formation, or intravenous immunoglobulin treatment response in the Taiwanese population.

原文英語
頁(從 - 到)840-845
頁數6
期刊Journal of Human Genetics
56
發行號12
DOIs
出版狀態已發佈 - 12月 21 2011
對外發佈

ASJC Scopus subject areas

  • 遺傳學(臨床)
  • 遺傳學

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