Polyketides with Anti-neuroinflammatory Activity fromTheissenia cinerea

Meng Hsuan Hsieh, George Hsiao, Chia Hao Chang, Yu Liang Yang, Yu Ming Ju, Yueh Hsiung Kuo, Tzong Huei Lee

研究成果: 雜誌貢獻回顧型文獻同行評審

3 引文 斯高帕斯(Scopus)

摘要

Theissenia cinerea89091602 is a previously reported plant-derived bioactive fungal strain, and the active principles separated from the extracts of its submerged culture were shown to exhibit potent anti-neuroinflammatory activities in both cellular study and animal testing. In a continuation of our previous investigation on the bioactive entities from this fungus, solid state fermentation was performed in an attempt to diversify the bioactive secondary metabolites. In the present study, five previously unreported polyketides, theissenophenol ( 1 ), theissenepoxide ( 2 ), theissenolactone D ( 3 ), theissenone ( 4 ), and theissenisochromanone ( 5 ), together with the known theissenolactone B ( 6 ), theissenolactone C ( 7 ), and arthrinone ( 8 ), were isolated and characterized through spectroscopic analysis and comparison with the literature data. The configurations of theissenepoxide ( 2 ) and theissenisochromanone ( 5 ) were further corroborated by single-crystal X-ray diffraction data analysis. Theissenone ( 4 ), theissenolactone B ( 6 ), theissenolactone C ( 7 ), and arthrinone ( 8 ) exhibited potent nitric oxide production inhibitory activities in murine brain microglial BV-2 cells with IC50values of 5.0 ± 1.0, 4.5 ± 0.6, 1.1 ± 0.1, and 3.2 ± 0.3 μM, respectively, without any significant cytotoxic effects.
原文英語
頁(從 - 到)1898-1903
頁數6
期刊Journal of Natural Products
84
發行號7
DOIs
出版狀態已發佈 - 7月 23 2021

ASJC Scopus subject areas

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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