Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice

Shu Lin Chang, Cicero L. Chang, Yi Ming Chiang, Rong-Hong Hsieh, Chii-Ruey Tzeng, Tung Kung Wu, Huey Kang Sytwu, Lie Fen Shyur, Wen Chin Yang

研究成果: 雜誌貢獻文章

52 引文 斯高帕斯(Scopus)

摘要

Compelling evidence suggests that infiltrating CD4+ type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain levels of blood sugar and insulin in NOD mice in a dose-dependent manner and elevated the serum IgE levels regulated by Th2 cytokines in NOD mice. Moreover, the butanol fraction inhibited the differentiation of naïve helper T (Th0) cells into Th1 cells but enhanced their transition into type 11 helper T (Th2) cells using an in vitro T cell differentiation assay. Two polyacetylenic compounds, 2-β-D- glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne, identified from the butanol fraction also prevented the onset of diabetes like the butanol fraction. The latter compound showed a stronger activity for T cell differentiation than the former. In summary, the butanol fraction of B. pilosa and its polyacetylenes can prevent diabetes plausibly via suppressing the differentiation of Th0 cells into Th1 cells and promoting that of Th0 cells into Th2 cells.
原文英語
頁(從 - 到)1045-1051
頁數7
期刊Planta Medica
70
發行號11
DOIs
出版狀態已發佈 - 十一月 2004

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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