Pneumococcal meningitis causes high morbidity or mortality in childhood despite the progress in medicine. Children with pneumococcal meningitis were identified and retrospectively reviewed. Forty-nine children were eligible, with mortality in 24.5% of all and neurological sequelae in 40.5% of survivors. In the analysis of clinical profiles, ventilator support (p = 0.001), septic shock (p < 0.001), multiple organ failure (p < 0.001) and lower cerebrospinal fluid (CSF) leukocyte count (p = 0.001) were more frequently found in non-survivors. Besides, CSF protein (p = 0.006) was higher in survivors with neurological sequelae. Initial dexamethasone usage and disease severity did not affect the occurrence of neurological sequelae. Multivariate logistic regression analysis revealed that CSF leukocyte count ≤ 200 mm-3 (p = 0.013) and protein level ≥ 330 g l-1 (p = 0.022) were significantly risk factors associated with poor outcomes, and physicians should be cautious if such conditions occur.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Infectious Diseases
Tsai, M. H., Chen, S. H., Hsu, C. Y., Yan, D. C., Yen, M. H., Chiu, C. H., Huang, Y. C., & Lin, T. Y. (2008). Pneumococcal meningitis in Taiwanese children: Emphasis on clinical outcomes and prognostic factors. Journal of Tropical Pediatrics, 54(6), 390-394. https://doi.org/10.1093/tropej/fmn046