Platelets stimulate aortic smooth muscle cell migration in vitro. Involvement of 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid

Junko Nakao, Toshiro Ooyama, Wen Chang Chang, Sei itsu Murota, Hajime Orimo

研究成果: 雜誌貢獻文章

68 引文 斯高帕斯(Scopus)

摘要

The migration of rat aortic smooth muscle cells was measured in modified Boyden chambers. Smooth muscle cells were motile in vitro and their migration was stimulated (time- and dose-dependently) by a platelet-derived factor. Treatment of platelets with indomethacin resulted in a significant increase in smooth muscle cell migration, whereas treatment with 5,8,11,14-eicosatetraenoic acid inhibited it. Purified 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid at a very low concentration (6 × 10-15-6 ×-13 g/ml) significantly stimulated smooth muscle cell migration. The locomotion induced by 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid was chemokinetic. These findings point to the physiological importance of a platelet 12-lipoxygenase product of arachidonic acid in the early phase of atherosclerosis.

原文英語
頁(從 - 到)143-150
頁數8
期刊Atherosclerosis
43
發行號2-3
DOIs
出版狀態已發佈 - 1982
對外發佈Yes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

指紋 深入研究「Platelets stimulate aortic smooth muscle cell migration in vitro. Involvement of 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid」主題。共同形成了獨特的指紋。

  • 引用此