Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Cancer Research
Davis, P. J., Mousa, S. A., Schechter, G. P., & Lin, H. Y. (2020). Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis. Hormones and Cancer, 11(1), 13-16. https://doi.org/10.1007/s12672-019-00371-4