Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Paul J. Davis, Shaker A. Mousa, Geraldine P. Schechter, Hung Yun Lin

研究成果: 雜誌貢獻回顧型文獻同行評審

1 引文 斯高帕斯(Scopus)

摘要

Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.
原文英語
頁(從 - 到)13-16
頁數4
期刊Hormones and Cancer
11
發行號1
DOIs
出版狀態已發佈 - 二月 1 2020

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cancer Research

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