Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy

Yung Yang Lin, Fu Jung Hsiao, Yang Hsin Shih, Chun Hing Yiu, Der Jen Yen, Sheong Yeong Kwan, Tai-Tong Wong, Zin An Wu, Low Tone Ho

研究成果: 雜誌貢獻文章同行評審

41 引文 斯高帕斯(Scopus)

摘要

The magnetic equivalent (MMNm) of mismatch negativity may reflect auditory discrimination and sensory memory. To study whether temporal lobe epilepsy (TLE) affects automatic central auditory-change processing, we recorded magnetoencephalographic (MEG) responses to standard and duration-deviant sounds in 12 TLE patients and 12 age-matched controls, and repeated MEG measurement in 8 patients 6-30 months following epilepsy surgery and in 6 controls 3-8 months after their first measurement. We compared the MMNm between patients and controls, and also evaluated intertrial phase coherences as indexed by phase-locking factors (PLF) using wavelet-based analyses. We observed longer MMNm latencies for patients than for controls. Dipole modeling and minimum-current estimates together showed bi-frontotemporal sources for MMNm. The phase locking across trials was dominant at the 4- to 14-Hz band, and the main difference in PLF between deviant- and standard-evoked responses occurred in the time frame of 150-250 ms after stimulus onset. Notably, in the 5 patients who became seizure free after removal of right temporal epileptic focus, the phase-locking phenomena resulting from deviant stimuli were enhanced, and even more distributed in the frontotemporal regions. We conclude that mesial TLE might affect auditory-change detection, and a successful surgery causes a possible plastic change in phase locking of deviant-evoked signals.

原文英語
頁(從 - 到)2516-2525
頁數10
期刊Cerebral Cortex
17
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2007
對外發佈

ASJC Scopus subject areas

  • 認知神經科學
  • 細胞與分子神經科學

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