摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 52-59 |
頁數 | 8 |
期刊 | Environmental Research |
卷 | 171 |
DOIs | |
出版狀態 | 已發佈 - 四月 1 2019 |
指紋
ASJC Scopus subject areas
- Biochemistry
- Environmental Science(all)
引用此文
Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan. / Su, Chien Tien; Hsieh, Ru Lan; Chung, Chi Jung; Huang, Pai Tsang; Lin, Ying Chin; Ao, Pui Lam; Shiue, Horng Sheng; Chen, Wei Jen; Huang, Shiau Rung; Lin, Ming I.; Mu, Shu Chi; Hsueh, Yu Mei.
於: Environmental Research, 卷 171, 01.04.2019, p. 52-59.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan
AU - Su, Chien Tien
AU - Hsieh, Ru Lan
AU - Chung, Chi Jung
AU - Huang, Pai Tsang
AU - Lin, Ying Chin
AU - Ao, Pui Lam
AU - Shiue, Horng Sheng
AU - Chen, Wei Jen
AU - Huang, Shiau Rung
AU - Lin, Ming I.
AU - Mu, Shu Chi
AU - Hsueh, Yu Mei
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Inefficient arsenic methylation capacity has been associated with developmental delay in preschool children. Selenium has antioxidant and anti-inflammatory properties that protect experimental animals from chemically induced neurotoxicity. The present study was designed to explore whether plasma selenium levels affects arsenic methylation capacity related to developmental delay in preschool children. A case-control study was conducted from August 2010 to March 2014. All participants were recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In total, 178 children with a developmental delay and 88 children without a delay were recruited. High-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry were used to determine urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV). Plasma selenium levels were measured by inductively coupled plasma mass spectrometry. As results, plasma selenium concentration was significantly inversely associated with the odds ratio (OR) of developmental delay. Plasma selenium concentration was positively associated with arsenic methylation capacity [percentage of inorganic arsenic and percentage of MMAV (MMAV%) decreased, and percentage of DMAV (DMAV%) increased]. High plasma selenium concentration and high DMA% significantly and additively interacted to decrease the OR of developmental delay; the OR and 95% confidence interval were 0.40 (0.18–0.90). This is the first study to show a combined dose-response effect of plasma selenium concentration and that efficient arsenic methylation capacity decreased the OR of developmental delay in preschool children.
AB - Inefficient arsenic methylation capacity has been associated with developmental delay in preschool children. Selenium has antioxidant and anti-inflammatory properties that protect experimental animals from chemically induced neurotoxicity. The present study was designed to explore whether plasma selenium levels affects arsenic methylation capacity related to developmental delay in preschool children. A case-control study was conducted from August 2010 to March 2014. All participants were recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In total, 178 children with a developmental delay and 88 children without a delay were recruited. High-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry were used to determine urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV). Plasma selenium levels were measured by inductively coupled plasma mass spectrometry. As results, plasma selenium concentration was significantly inversely associated with the odds ratio (OR) of developmental delay. Plasma selenium concentration was positively associated with arsenic methylation capacity [percentage of inorganic arsenic and percentage of MMAV (MMAV%) decreased, and percentage of DMAV (DMAV%) increased]. High plasma selenium concentration and high DMA% significantly and additively interacted to decrease the OR of developmental delay; the OR and 95% confidence interval were 0.40 (0.18–0.90). This is the first study to show a combined dose-response effect of plasma selenium concentration and that efficient arsenic methylation capacity decreased the OR of developmental delay in preschool children.
KW - Arsenic
KW - Arsenic methylation
KW - Developmental delay
KW - Selenium
UR - http://www.scopus.com/inward/record.url?scp=85059847133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059847133&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2019.01.003
DO - 10.1016/j.envres.2019.01.003
M3 - Article
AN - SCOPUS:85059847133
VL - 171
SP - 52
EP - 59
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
ER -