Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan

Chien Tien Su, Ru Lan Hsieh, Chi Jung Chung, Pai Tsang Huang, Ying Chin Lin, Pui Lam Ao, Horng Sheng Shiue, Wei Jen Chen, Shiau Rung Huang, Ming I. Lin, Shu Chi Mu, Yu Mei Hsueh

研究成果: 雜誌貢獻 › 文章

5 引文 (Scopus)

摘要

Inefficient arsenic methylation capacity has been associated with developmental delay in preschool children. Selenium has antioxidant and anti-inflammatory properties that protect experimental animals from chemically induced neurotoxicity. The present study was designed to explore whether plasma selenium levels affects arsenic methylation capacity related to developmental delay in preschool children. A case-control study was conducted from August 2010 to March 2014. All participants were recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In total, 178 children with a developmental delay and 88 children without a delay were recruited. High-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry were used to determine urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV). Plasma selenium levels were measured by inductively coupled plasma mass spectrometry. As results, plasma selenium concentration was significantly inversely associated with the odds ratio (OR) of developmental delay. Plasma selenium concentration was positively associated with arsenic methylation capacity [percentage of inorganic arsenic and percentage of MMAV (MMAV%) decreased, and percentage of DMAV (DMAV%) increased]. High plasma selenium concentration and high DMA% significantly and additively interacted to decrease the OR of developmental delay; the OR and 95% confidence interval were 0.40 (0.18–0.90). This is the first study to show a combined dose-response effect of plasma selenium concentration and that efficient arsenic methylation capacity decreased the OR of developmental delay in preschool children.
原文英語
頁（從 - 到）52-59
頁數8
期刊Environmental Research
卷171
DOIs
出版狀態已發佈 - 四月 1 2019

指紋

Methylation
methylation
Arsenic
Preschool Children
Selenium
selenium
Taiwan
arsenic
Plasmas
plasma
Odds Ratio
Cacodylic Acid
Inductively coupled plasma mass spectrometry
Atomic absorption spectrometry
arsenite
acid
High performance liquid chromatography
Dynamic mechanical analysis
arsenate
Hydrides

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

引用此文

Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan. / Su, Chien Tien; Hsieh, Ru Lan; Chung, Chi Jung; Huang, Pai Tsang; Lin, Ying Chin; Ao, Pui Lam; Shiue, Horng Sheng; Chen, Wei Jen; Huang, Shiau Rung; Lin, Ming I.; Mu, Shu Chi; Hsueh, Yu Mei.

於: Environmental Research, 卷 171, 01.04.2019, p. 52-59.

研究成果: 雜誌貢獻 › 文章

Su, CT, Hsieh, RL, Chung, CJ, Huang, PT, Lin, YC, Ao, PL, Shiue, HS, Chen, WJ, Huang, SR, Lin, MI, Mu, SC & Hsueh, YM 2019, 'Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan', Environmental Research, 卷 171, 頁 52-59. https://doi.org/10.1016/j.envres.2019.01.003
Su CT, Hsieh RL, Chung CJ, Huang PT, Lin YC, Ao PL 等. Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan. Environmental Research. 2019 4月 1;171:52-59. https://doi.org/10.1016/j.envres.2019.01.003
Su, Chien Tien ; Hsieh, Ru Lan ; Chung, Chi Jung ; Huang, Pai Tsang ; Lin, Ying Chin ; Ao, Pui Lam ; Shiue, Horng Sheng ; Chen, Wei Jen ; Huang, Shiau Rung ; Lin, Ming I. ; Mu, Shu Chi ; Hsueh, Yu Mei. / Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan. 於: Environmental Research. 2019 ; 卷 171. 頁 52-59.
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abstract = "Inefficient arsenic methylation capacity has been associated with developmental delay in preschool children. Selenium has antioxidant and anti-inflammatory properties that protect experimental animals from chemically induced neurotoxicity. The present study was designed to explore whether plasma selenium levels affects arsenic methylation capacity related to developmental delay in preschool children. A case-control study was conducted from August 2010 to March 2014. All participants were recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In total, 178 children with a developmental delay and 88 children without a delay were recruited. High-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry were used to determine urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV). Plasma selenium levels were measured by inductively coupled plasma mass spectrometry. As results, plasma selenium concentration was significantly inversely associated with the odds ratio (OR) of developmental delay. Plasma selenium concentration was positively associated with arsenic methylation capacity [percentage of inorganic arsenic and percentage of MMAV (MMAV{\%}) decreased, and percentage of DMAV (DMAV{\%}) increased]. High plasma selenium concentration and high DMA{\%} significantly and additively interacted to decrease the OR of developmental delay; the OR and 95{\%} confidence interval were 0.40 (0.18–0.90). This is the first study to show a combined dose-response effect of plasma selenium concentration and that efficient arsenic methylation capacity decreased the OR of developmental delay in preschool children.",
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