Plasma RANTES and eotaxin levels are correlated with the severity of chronic rhinosinusitis

Pin Zhir Chao, Chi Ming Chou, Chen Ho Chen

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

Eosinophilia occurs in up to 75-90% of nasal polyps in Caucasians. The chemokines eotaxin and RANTES increase eosinophil recruitment, activation, and survival, and these chemokines are significantly expressed in nasal polyps. We hypothesized that eotaxin and RANTES plasma levels might be correlated with disease severity. We compared the eotaxin and RANTES plasma levels in 20 Taiwanese patients with chronic rhinosinusitis and nasal polyps and 20 Taiwanese healthy controls. Eotaxin and RANTES plasma levels were measured by ELISA and disease severity was scored by CT scans. Compared to controls, patients with nasal polyps had significantly elevated plasma levels of eotaxin and RANTES and increased peripheral blood eosinophils (p <0.001). Eotaxin plasma levels were significantly correlated with disease severity in patients with chronic rhinosinusitis to a greater extent than were RANTES levels. RANTES and eotaxin levels were also positively correlated with the percentages of peripheral blood eosinophils. Eotaxin plasma levels are significantly correlated with disease severity in Taiwanese patients with nasal polyposis to a greater degree than are RANTES levels. Additional studies are needed to assess whether eotaxin plasma levels can be used to monitor disease progression and attenuation.
原文英語
頁(從 - 到)2343-2348
頁數6
期刊European Archives of Oto-Rhino-Laryngology
269
發行號11
DOIs
出版狀態已發佈 - 十一月 2012

    指紋

ASJC Scopus subject areas

  • Otorhinolaryngology

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