Plasma homovanillic acid concentrations in catatonia

Georg Northoff, Lothar Demisch, Jens Wenke, Burkhard Pflug

研究成果: 雜誌貢獻文章

29 引文 (Scopus)

摘要

We investigated the dopamine metabolite plasma homovanillic acid (plasma HVA) levels in 37 catatonic patients on the day of admission before initial medication as well as in 17 healthy controls. In a prospective study catatonic syndrome was diagnosed according to criteria of Lohr and Wiesniwski (1987) and Rosebush et al (1990) whereas comorbid diagnosis was made by Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, revised (DSM III/R) (APA 1987). On the day of admission blood samples were taken before initial medication. Compared to controls (80.1 ± 40.1 pmol/mL) catatonic patients showed significantly (p 0.0286) increased plasma HVA (140.9 ± 53.6 pmol/mL). Catatonic patients free of neuroleptic medication (n = 21) differed significantly (p = 0.0416) from controls whereas neuroleptically treated catatonics (n = 16) did not. Our findings of increased plasma HVA in catatonia are explained by an alteration in either mesolimbic or mesocortical dopaminergic function, as is assumed in the case of schizophrenia. As an alternative, it may be due to increased nigrostriatal function, which can lead, as-shown in animal experiments with the dopamine agonist amphetamine, to hypokinetic states resembling catatonia in humans.
原文英語
頁(從 - 到)436-443
頁數8
期刊Biological Psychiatry
39
發行號6
DOIs
出版狀態已發佈 - 三月 15 1996

指紋

Catatonia
Homovanillic Acid
Diagnostic and Statistical Manual of Mental Disorders
Dopamine Agonists
Amphetamine
Antipsychotic Agents
Dopamine
Schizophrenia
Prospective Studies

ASJC Scopus subject areas

  • Biological Psychiatry

引用此文

Plasma homovanillic acid concentrations in catatonia. / Northoff, Georg; Demisch, Lothar; Wenke, Jens; Pflug, Burkhard.

於: Biological Psychiatry, 卷 39, 編號 6, 15.03.1996, p. 436-443.

研究成果: 雜誌貢獻文章

Northoff, Georg ; Demisch, Lothar ; Wenke, Jens ; Pflug, Burkhard. / Plasma homovanillic acid concentrations in catatonia. 於: Biological Psychiatry. 1996 ; 卷 39, 編號 6. 頁 436-443.
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