Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia

Shang Jyh Kao, Chun Yi Chuang, Chih Hsin Tang, Chien Huang Lin, Mauo Ying Bien, Ming Chih Yu, Kuan Jen Bai, Shun Fa Yang, Ming Hsien Chien

研究成果: 雜誌貢獻文章

22 引文 (Scopus)

摘要

Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.
原文英語
頁(從 - 到)445-451
頁數7
期刊Clinical Chemistry and Laboratory Medicine
52
發行號3
DOIs
出版狀態已發佈 - 2014

指紋

Endothelial cells
Plasma Cells
Pneumonia
Endothelial Cells
Plasmas
Molecules
Physiology
APACHE
C-Reactive Protein
Blood
Health
Anti-Bacterial Agents
Immunosorbents
Proteoglycans
Vascular Endothelium
Leukocyte Count
Assays
Intercellular Signaling Peptides and Proteins
Cells
Sepsis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

引用此文

Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia. / Kao, Shang Jyh; Chuang, Chun Yi; Tang, Chih Hsin; Lin, Chien Huang; Bien, Mauo Ying; Yu, Ming Chih; Bai, Kuan Jen; Yang, Shun Fa; Chien, Ming Hsien.

於: Clinical Chemistry and Laboratory Medicine, 卷 52, 編號 3, 2014, p. 445-451.

研究成果: 雜誌貢獻文章

@article{75e96682d8bb4797b46e941f1a72fd39,
title = "Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia",
abstract = "Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.",
keywords = "Biochemical marker, Community-acquired pneumonia, Endothelial cell-specific molecule-1, Pneumonia severity index",
author = "Kao, {Shang Jyh} and Chuang, {Chun Yi} and Tang, {Chih Hsin} and Lin, {Chien Huang} and Bien, {Mauo Ying} and Yu, {Ming Chih} and Bai, {Kuan Jen} and Yang, {Shun Fa} and Chien, {Ming Hsien}",
year = "2014",
doi = "10.1515/cclm-2013-0638",
language = "English",
volume = "52",
pages = "445--451",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "3",

}

TY - JOUR

T1 - Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia

AU - Kao, Shang Jyh

AU - Chuang, Chun Yi

AU - Tang, Chih Hsin

AU - Lin, Chien Huang

AU - Bien, Mauo Ying

AU - Yu, Ming Chih

AU - Bai, Kuan Jen

AU - Yang, Shun Fa

AU - Chien, Ming Hsien

PY - 2014

Y1 - 2014

N2 - Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

AB - Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

KW - Biochemical marker

KW - Community-acquired pneumonia

KW - Endothelial cell-specific molecule-1

KW - Pneumonia severity index

UR - http://www.scopus.com/inward/record.url?scp=84896114020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896114020&partnerID=8YFLogxK

U2 - 10.1515/cclm-2013-0638

DO - 10.1515/cclm-2013-0638

M3 - Article

C2 - 24108208

AN - SCOPUS:84896114020

VL - 52

SP - 445

EP - 451

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

IS - 3

ER -