Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

Chi Chang Huang, Yu Tang Tung, Kai Chung Cheng, Jyh Horng Wu

研究成果: 雜誌貢獻 › 文章

14 引文 (Scopus)

摘要

Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.
原文英語
頁（從 - 到）726-731
頁數6
期刊Food Chemistry
卷125
發行號2
DOIs
出版狀態已發佈 - 三月 15 2011
對外發佈Yes

指紋

carbon tetrachloride
Carbon Tetrachloride
Vitis
Liver
Silymarin
grapes
liver
stems
Macrophages
Bioelectric potentials
resveratrol
mice
Wounds and Injuries
Transaminases
Bioactivity
Medicine
Lipopolysaccharides
Assays
Anti-Inflammatory Agents
viniferins

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

引用此文

Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice. / Huang, Chi Chang; Tung, Yu Tang; Cheng, Kai Chung; Wu, Jyh Horng.

於: Food Chemistry, 卷 125, 編號 2, 15.03.2011, p. 726-731.

研究成果: 雜誌貢獻 › 文章

Huang, CC, Tung, YT, Cheng, KC & Wu, JH 2011, 'Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice', Food Chemistry, 卷 125, 編號 2, 頁 726-731. https://doi.org/10.1016/j.foodchem.2010.09.085
Huang CC, Tung YT, Cheng KC, Wu JH. Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice. Food Chemistry. 2011 3月 15;125(2):726-731. https://doi.org/10.1016/j.foodchem.2010.09.085
Huang, Chi Chang ; Tung, Yu Tang ; Cheng, Kai Chung ; Wu, Jyh Horng. / Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice. 於: Food Chemistry. 2011 ; 卷 125, 編號 2. 頁 726-731.
@article{b5cff131475145469859e31f7247861b,
title = "Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice",
abstract = "Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.",
keywords = "Hepatoprotection, Resveratrol derivatives, Stem, Vitis kelungensis, Wild grape",
author = "Huang, {Chi Chang} and Tung, {Yu Tang} and Cheng, {Kai Chung} and Wu, {Jyh Horng}",
year = "2011",
month = "3",
day = "15",
doi = "10.1016/j.foodchem.2010.09.085",
language = "English",
volume = "125",
pages = "726--731",
journal = "Food Chemistry",
issn = "0308-8146",
publisher = "Elsevier Ltd",
number = "2",

}

TY - JOUR

T1 - Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

AU - Huang, Chi Chang

AU - Tung, Yu Tang

AU - Cheng, Kai Chung

AU - Wu, Jyh Horng

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.

AB - Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.

KW - Hepatoprotection

KW - Resveratrol derivatives

KW - Stem

KW - Vitis kelungensis

KW - Wild grape

UR - http://www.scopus.com/inward/record.url?scp=78049427355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049427355&partnerID=8YFLogxK

U2 - 10.1016/j.foodchem.2010.09.085

DO - 10.1016/j.foodchem.2010.09.085

M3 - Article

AN - SCOPUS:78049427355

VL - 125

SP - 726

EP - 731

JO - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

IS - 2

ER -

存取文件