Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

Chi Chang Huang, Yu Tang Tung, Kai Chung Cheng, Jyh Horng Wu

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.
原文英語
頁(從 - 到)726-731
頁數6
期刊Food Chemistry
125
發行號2
DOIs
出版狀態已發佈 - 三月 15 2011
對外發佈

ASJC Scopus subject areas

  • 食品科學
  • 分析化學

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