Phyto-SERM constitutes from Flemingia macrophylla

Wan Chun Lai, Ya Ting Tsui, Abdel Nasser B Singab, Mohamed El-Shazly, Ying Chi Du, Tsong Long Hwang, Chin Chung Wu, Ming Hong Yen, Ching Kuo Lee, Ming Feng Hou, Yang Chang Wu, Fang Rong Chang

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots' methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).

原文英語
頁(從 - 到)15578-15594
頁數17
期刊International Journal of Molecular Sciences
14
發行號8
DOIs
出版狀態已發佈 - 2013

指紋

estrogens
Selective Estrogen Receptor Modulators
Phytoestrogens
Spectroscopic analysis
Genetically Modified Plants
Fractionation
Soybeans
Modulators
modulators
Assays
Estrogens
Anti-Inflammatory Agents
soybeans
spectroscopic analysis
fractionation

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

引用此文

Lai, W. C., Tsui, Y. T., Singab, A. N. B., El-Shazly, M., Du, Y. C., Hwang, T. L., ... Chang, F. R. (2013). Phyto-SERM constitutes from Flemingia macrophylla. International Journal of Molecular Sciences, 14(8), 15578-15594. https://doi.org/10.3390/ijms140815578

Phyto-SERM constitutes from Flemingia macrophylla. / Lai, Wan Chun; Tsui, Ya Ting; Singab, Abdel Nasser B; El-Shazly, Mohamed; Du, Ying Chi; Hwang, Tsong Long; Wu, Chin Chung; Yen, Ming Hong; Lee, Ching Kuo; Hou, Ming Feng; Wu, Yang Chang; Chang, Fang Rong.

於: International Journal of Molecular Sciences, 卷 14, 編號 8, 2013, p. 15578-15594.

研究成果: 雜誌貢獻文章

Lai, WC, Tsui, YT, Singab, ANB, El-Shazly, M, Du, YC, Hwang, TL, Wu, CC, Yen, MH, Lee, CK, Hou, MF, Wu, YC & Chang, FR 2013, 'Phyto-SERM constitutes from Flemingia macrophylla', International Journal of Molecular Sciences, 卷 14, 編號 8, 頁 15578-15594. https://doi.org/10.3390/ijms140815578
Lai WC, Tsui YT, Singab ANB, El-Shazly M, Du YC, Hwang TL 等. Phyto-SERM constitutes from Flemingia macrophylla. International Journal of Molecular Sciences. 2013;14(8):15578-15594. https://doi.org/10.3390/ijms140815578
Lai, Wan Chun ; Tsui, Ya Ting ; Singab, Abdel Nasser B ; El-Shazly, Mohamed ; Du, Ying Chi ; Hwang, Tsong Long ; Wu, Chin Chung ; Yen, Ming Hong ; Lee, Ching Kuo ; Hou, Ming Feng ; Wu, Yang Chang ; Chang, Fang Rong. / Phyto-SERM constitutes from Flemingia macrophylla. 於: International Journal of Molecular Sciences. 2013 ; 卷 14, 編號 8. 頁 15578-15594.
@article{1da42e2ef314452490c04a7f43a3d49d,
title = "Phyto-SERM constitutes from Flemingia macrophylla",
abstract = "The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots' methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).",
keywords = "Flemichin E, Flemingia macrophylla, Fleminigin, Menopausal, pER8:GUS, Phytoestrogen",
author = "Lai, {Wan Chun} and Tsui, {Ya Ting} and Singab, {Abdel Nasser B} and Mohamed El-Shazly and Du, {Ying Chi} and Hwang, {Tsong Long} and Wu, {Chin Chung} and Yen, {Ming Hong} and Lee, {Ching Kuo} and Hou, {Ming Feng} and Wu, {Yang Chang} and Chang, {Fang Rong}",
year = "2013",
doi = "10.3390/ijms140815578",
language = "English",
volume = "14",
pages = "15578--15594",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "8",

}

TY - JOUR

T1 - Phyto-SERM constitutes from Flemingia macrophylla

AU - Lai, Wan Chun

AU - Tsui, Ya Ting

AU - Singab, Abdel Nasser B

AU - El-Shazly, Mohamed

AU - Du, Ying Chi

AU - Hwang, Tsong Long

AU - Wu, Chin Chung

AU - Yen, Ming Hong

AU - Lee, Ching Kuo

AU - Hou, Ming Feng

AU - Wu, Yang Chang

AU - Chang, Fang Rong

PY - 2013

Y1 - 2013

N2 - The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots' methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).

AB - The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots' methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).

KW - Flemichin E

KW - Flemingia macrophylla

KW - Fleminigin

KW - Menopausal

KW - pER8:GUS

KW - Phytoestrogen

UR - http://www.scopus.com/inward/record.url?scp=84881038388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881038388&partnerID=8YFLogxK

U2 - 10.3390/ijms140815578

DO - 10.3390/ijms140815578

M3 - Article

C2 - 23896592

AN - SCOPUS:84881038388

VL - 14

SP - 15578

EP - 15594

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 8

ER -