Phylogeography of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) in southern China and some surrounding areas

Jian Peng, Zhang Ping He, Shuai Zhang, Zhao Rong Lun, Zhong Dao Wu, Chia Kwung Fan, Christopher L. Brown, Po Ching Cheng, Shih Yi Peng, Ting Bao Yang

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Angiostrongylus cantonensis is of increasing public health importance as the main zoonotic pathogen causing eosinophilic meningitis or meningoencephalitis, which has been documented all over the world. However, there are very limited studies about its phylogeography and spread pattern. In the present study, the phylogeography of A. cantonensis in southern China (including Taiwan) and partial areas of Southeast Asia were studied based on the sequences of complete mitochondrial cytochrome b (Cytb) gene. A total of 520 individuals of A. cantonensis obtained from 13 localities were sequenced for the analyses and grouped into 42 defined haplotypes. The phylogenetic tree (NJ tree and BI tree) revealed a characteristic distribution pattern of the four main lineages, with detectable geographic structure. Genetic differentiation among populations was significant, but demographic expansion could not be detected by either neutrality tests or mismatch distribution analysis, which implied a low gene flow among the local populations in different regions where the samples were collected. Two unique lineages of the A. cantonensis population in Taiwan were detected, which suggests its multiple origin in the island. Populations in Hekou (China) and Laos showed the highest genetic diversities, which were supported by both genetic diversity indices and AMOVA. These results together infer that the area around Thailand or Hekou in Yunnan province, China are the most likely origins of Angiostrongylus cantonensis.
原文英語
文章編號e0005776
期刊PLoS Neglected Tropical Diseases
11
發行號8
DOIs
出版狀態已發佈 - 八月 1 2017

指紋

Angiostrongylus cantonensis
Phylogeography
Nematoda
China
Taiwan
Population
Laos
Southeastern Asia
Meningoencephalitis
Cytochromes b
Gene Flow
Zoonoses
Thailand
Meningitis
Islands
Haplotypes
Public Health
Demography
Genes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

引用此文

Phylogeography of Angiostrongylus cantonensis (Nematoda : Angiostrongylidae) in southern China and some surrounding areas. / Peng, Jian; He, Zhang Ping; Zhang, Shuai; Lun, Zhao Rong; Wu, Zhong Dao; Fan, Chia Kwung; Brown, Christopher L.; Cheng, Po Ching; Peng, Shih Yi; Yang, Ting Bao.

於: PLoS Neglected Tropical Diseases, 卷 11, 編號 8, e0005776, 01.08.2017.

研究成果: 雜誌貢獻文章

Peng, Jian ; He, Zhang Ping ; Zhang, Shuai ; Lun, Zhao Rong ; Wu, Zhong Dao ; Fan, Chia Kwung ; Brown, Christopher L. ; Cheng, Po Ching ; Peng, Shih Yi ; Yang, Ting Bao. / Phylogeography of Angiostrongylus cantonensis (Nematoda : Angiostrongylidae) in southern China and some surrounding areas. 於: PLoS Neglected Tropical Diseases. 2017 ; 卷 11, 編號 8.
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abstract = "Angiostrongylus cantonensis is of increasing public health importance as the main zoonotic pathogen causing eosinophilic meningitis or meningoencephalitis, which has been documented all over the world. However, there are very limited studies about its phylogeography and spread pattern. In the present study, the phylogeography of A. cantonensis in southern China (including Taiwan) and partial areas of Southeast Asia were studied based on the sequences of complete mitochondrial cytochrome b (Cytb) gene. A total of 520 individuals of A. cantonensis obtained from 13 localities were sequenced for the analyses and grouped into 42 defined haplotypes. The phylogenetic tree (NJ tree and BI tree) revealed a characteristic distribution pattern of the four main lineages, with detectable geographic structure. Genetic differentiation among populations was significant, but demographic expansion could not be detected by either neutrality tests or mismatch distribution analysis, which implied a low gene flow among the local populations in different regions where the samples were collected. Two unique lineages of the A. cantonensis population in Taiwan were detected, which suggests its multiple origin in the island. Populations in Hekou (China) and Laos showed the highest genetic diversities, which were supported by both genetic diversity indices and AMOVA. These results together infer that the area around Thailand or Hekou in Yunnan province, China are the most likely origins of Angiostrongylus cantonensis.",
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