Photoproducts of indomethacin

Pen Yuan Lin, Fu An Chen, An Bang Wu, Su Hui Chao, Yu Tang Peng, Vickie M H Lee, Chau Yang Chen

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

In a photochemical chamber, a sample of 27.9 mM indomethacin (IN) in methanol was exposed to a Philips 400-W UV lamp for 5 days in normal atmosphere. Four photoproducts were separated using high-performance liquid chromatography, and their structures were elucidated by various spectroscopic methods, including liquid chromatography–electrospray ionization–mass spectrometry. A reaction scheme of IN in methanol is proposed: The photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce an aldehyde. A β-hydroxy-γ-lactone was also formed through a photochemical [2 + 2] cycloaddition, and its structure was confirmed by single-crystal X-ray diffraction.

原文英語
頁(從 - 到)1777-1783
頁數7
期刊Journal of the Iranian Chemical Society
13
發行號10
DOIs
出版狀態已發佈 - 十月 1 2016

ASJC Scopus subject areas

  • 化學 (全部)

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