Photolysis of NSAIDs. Part 3: Structural elucidation of photoproducts of tolmetin in methanol

Ming Thau Sheu, Jender Wu, Chih Jui Chen, Su Hui Chao, An-Bang Wu

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Photolysis of tolmetin in methanol produces eight photoproducts via a novel α-cleavage of a ketone, decarboxylation, and oxidation. A sample of 10 mM tolmetin in methanol was photo-irradiated with a Hanovia 200 W high-pressure quartz Hg lamp for four days. In total, eight photoproducts were observed from the HPLC chromatogram. Three major photoproducts were separated, and their structures were elucidated by spectroscopic methods. The structures of all photoproducts were further determined by LC-ESI-MS. A reaction scheme of tolmetin was proposed.

原文英語
頁(從 - 到)8107-8109
頁數3
期刊Tetrahedron Letters
45
發行號43
DOIs
出版狀態已發佈 - 十月 18 2004

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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