Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion

Chuan Hang Yu, Hsin Ming Chen, Hsien Yen Hung, Shih Jung Cheng, Tsuimin Tsai, Chun Pin Chiang

研究成果: 雜誌貢獻文章

38 引文 (Scopus)

摘要

Our previous studies showed that oral verrucous hyperplasia (OVH) lesions can be successfully treated with a topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) protocol using a 635-nm light-emitting diode light source. In this study, we report the clinical outcomes of 36 OVH lesions treated by this protocol and assess what clinicopathological parameters of OVH lesions could influence PDT treatment outcomes. We found that all the 36 OVH lesions showed complete response (CR) after an average of 3.8 (range, 1-6) treatments of topical ALA-PDT. OVH lesions with an clinical appearance of a mass, with the greatest diameter 40 μm (p = 0.003), respectively. Multivariate analysis showed that only the clinical appearance of OVH lesions was the independent factor (p = 0.0069). We conclude that complete regression of OVH lesions can be achieved by less than seven treatments of topical ALA-PDT once a week. The PDT treatment outcome for OVH depends on the outer appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion.

原文英語
頁(從 - 到)595-600
頁數6
期刊Oral Oncology
44
發行號6
DOIs
出版狀態已發佈 - 六月 2008

指紋

Photochemotherapy
Keratins
Hyperplasia
Color
Aminolevulinic Acid
Light
Multivariate Analysis
Therapeutics

ASJC Scopus subject areas

  • Oncology

引用此文

Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion. / Yu, Chuan Hang; Chen, Hsin Ming; Hung, Hsien Yen; Cheng, Shih Jung; Tsai, Tsuimin; Chiang, Chun Pin.

於: Oral Oncology, 卷 44, 編號 6, 06.2008, p. 595-600.

研究成果: 雜誌貢獻文章

Yu, Chuan Hang ; Chen, Hsin Ming ; Hung, Hsien Yen ; Cheng, Shih Jung ; Tsai, Tsuimin ; Chiang, Chun Pin. / Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion. 於: Oral Oncology. 2008 ; 卷 44, 編號 6. 頁 595-600.
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abstract = "Our previous studies showed that oral verrucous hyperplasia (OVH) lesions can be successfully treated with a topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) protocol using a 635-nm light-emitting diode light source. In this study, we report the clinical outcomes of 36 OVH lesions treated by this protocol and assess what clinicopathological parameters of OVH lesions could influence PDT treatment outcomes. We found that all the 36 OVH lesions showed complete response (CR) after an average of 3.8 (range, 1-6) treatments of topical ALA-PDT. OVH lesions with an clinical appearance of a mass, with the greatest diameter 40 μm (p = 0.003), respectively. Multivariate analysis showed that only the clinical appearance of OVH lesions was the independent factor (p = 0.0069). We conclude that complete regression of OVH lesions can be achieved by less than seven treatments of topical ALA-PDT once a week. The PDT treatment outcome for OVH depends on the outer appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion.",
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AU - Tsai, Tsuimin

AU - Chiang, Chun Pin

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