Serial chromosomal analyses were performed in an untreated patient who demonstrated little or no hæmatological disease for over 5 years before the development of overt blastic leukæmia. The Philadelphia chromosome (Ph') was present in a small percentage of marrow cells during the preleukæmic period. Hæmatological remission of the blastic leukæmia was achieved with hæmopoiesis derived from a Ph' positive cell line. The Ph' chromosome was an indicator of the preleukæmic state in the absence of other abnormalities.
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