Pharmacological effects of butylidenephthalide

W. C. Ko, L. D. Chang, G. Y. Wang, L. C. Lin

研究成果: 雜誌貢獻文章

29 引文 斯高帕斯(Scopus)

摘要

The pharmacological effects of synthetic butylidenephthalide (Bdph), the most potent antispasmodic agent found in the neutral oil of Ligusticum wallichii Franch., were examined in this study. In vivo, Bdph exerted a significant antihypertensive effect in anaesthetized renal hypertensive rats at a dose of 30 mg/kg (i.v. or i.p.), or 60 mg/kg (p.o.). Bdph antagonized noradrenaline (NA) induced increases in blood pressure in anaesthetized normotensive rats. In addition, Bdph prevented the pituitrin-induced T-wave lowering of the ECG in anaesthetized rats. It also dose-dependently decreased coronary arterial pressure in dogs. It is concluded that Bdph dilates coronary vessels. In vitro, Bdph non-competitively antagonized adrenaline-induced contraction in isolated rabbit aortic strips. It also significantly antagonized the NA-induced maximum decrease in perfusion rate of isolated rabbit ears. However, the vasodilator effect may cause a heat loss because Bdph significantly lowered the rectal temperature of rats at ambient temperature of 20°C, but not at 30°C. Bdph might be a useful coronary dilator and antihypertensive drug.
原文英語
頁(從 - 到)321-326
頁數6
期刊Phytotherapy Research
8
發行號6
DOIs
出版狀態已發佈 - 1994

    指紋

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

引用此

Ko, W. C., Chang, L. D., Wang, G. Y., & Lin, L. C. (1994). Pharmacological effects of butylidenephthalide. Phytotherapy Research, 8(6), 321-326. https://doi.org/10.1002/ptr.2650080602