Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers

Yen An Chen, Kuang Yang Hsu

研究成果: 雜誌貢獻文章同行評審

摘要

The aim of presented study was to assess pharmacokinetic properties of fexofenadine in Taiwanese volunteers. Thirty-three healthy male subjects received 180mg fexofenadine. Blood samples were drawn at appropriate times. Drug concentrations of fexofenadine were measured by a LC/MS/MS method. Non-compartmental models were applied to describe the pharmacokinetic characters of fexofenadine. After oral administration of fexofenadine, the Tmaxwas 1.90±0.81h. The Cmaxwas 703.76±298.94ng/mL and AUC0-∞was 4582.52±1812.59hxng/mL. The elimination half-life of fexofenadine was 12.18±3.61h. One of the most important determinants was to prove the similar results in the pharmacokinetics of fexofenadine in Taiwan subjects compared with the reported data of other ethnic origin.

原文英語
頁(從 - 到)1261-1264
頁數4
期刊Pakistan Journal of Pharmaceutical Sciences
27
發行號5
出版狀態已發佈 - 九月 1 2014

ASJC Scopus subject areas

  • Pharmaceutical Science

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