Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits

Shih Ming Chen, Mei Yu Fan, Chia Chi Tseng, Yih Ho, Kuang Yang Hsu

研究成果: 雜誌貢獻文章同行評審

26 引文 斯高帕斯(Scopus)

摘要

Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). To investigate the pharmacokinetics and nephrotoxicity of AAs, rabbits were used in this study. The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were determined by a validated high-performance liquid chromatographic method. After intravenous administration of different doses (0.25, 0.5, 1.0, and 2.0 mg/kg) of aristolochic acid sodium (AANa) to 4 respective groups of rabbits (n=6 for each dose), linear relationships between the doses of AA I and AA II and the area under the plasma concentration curve (AUC) were found to exist (p

原文英語
頁(從 - 到)180-188
頁數9
期刊Toxicon
50
發行號2
DOIs
出版狀態已發佈 - 八月 2007

ASJC Scopus subject areas

  • Toxicology

指紋 深入研究「Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits」主題。共同形成了獨特的指紋。

引用此