Pharmacokinetics and bioavailability of caffeic acid after oral administration in rabbits

Yow Shieng Uang, Kuang Yang Hsu

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

The pharmacokinetics and bioavailability of caffeic acid (ca) were studied after oral administration in rabbits. three different doses (5, 10 and 25 mg/kg) of ca solution were orally administered to six rabbits with a one week washout period between each dose. The concentration-time profiles of caffeic acid showed a double peak phenomenon and the elimination phase was obviously different than after intravenous administration, indicating that CA shows 'flip-flop' pharmacokinetics. The pharmacokinetic parameters of the CL(total), CL(r), CL(nr), and absorption phase half-life showed no significant differences for each dose after oral administration. These results indicate that CA exhibits dose-independent pharmacokinetics after oral administration in the dose range of 5 to 25 mg/kg. The results also show that the values of the AUC and C(max) increased linearly with dose in the range of 5 to 25 mg/kg. The absolute bioavailability values of CA were 0.364 ± 0.052, 0.379 ± 0.037 and 0.402 ± 0.087 and the percentages of unchanged CA excreted in the urine were 23.2 ± 4.9, 22.7 ± 3.7 and 22.0 ± 5.3 % for doses of 5, 10 and 25 mg/kg, respectively. There were no significant differences in the absolute bioavailability and percentages of unchanged CA excreted in the urine over this dose range.

原文英語
頁(從 - 到)195-204
頁數10
期刊Chinese Pharmaceutical Journal
50
發行號4
出版狀態已發佈 - 八月 1998

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

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