Pharmacokinetic properties of ranitidine in Chinese people

O. Y.P. Hu, L. H. Pao, P. H. Chung, H. S. Tang

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

The pharmacokinetics and relative bioavailability of two different formulated ranitidine tablets were examined in 12 healthy young Chinese males at one week intervals in a randomized crossover design. Both ranitidine plasma and urine concentrations were measured by a sensitive, accurate and specific High Performance Liquid Chromatography method. No bioavailability differences were found between Glaxo's and Veteran's ranitidine products. However, larger apparent volume of distribution, higher total oral clearance and higher non-renal clearance were observed in Chinese. Further studies are needed to elucidate a higher rantidine dosage may be required for Chinese to achieve the desired plasma level.
原文英語
頁(從 - 到)328-335
頁數8
期刊Acta Gastro-Enterologica Belgica
54
發行號5-6
出版狀態已發佈 - 十二月 1 1991
對外發佈Yes

指紋

Ranitidine
Pharmacokinetics
Biological Availability
Veterans
Cross-Over Studies
Tablets
High Pressure Liquid Chromatography
Urine

ASJC Scopus subject areas

  • Gastroenterology

引用此文

Hu, O. Y. P., Pao, L. H., Chung, P. H., & Tang, H. S. (1991). Pharmacokinetic properties of ranitidine in Chinese people. Acta Gastro-Enterologica Belgica, 54(5-6), 328-335.

Pharmacokinetic properties of ranitidine in Chinese people. / Hu, O. Y.P.; Pao, L. H.; Chung, P. H.; Tang, H. S.

於: Acta Gastro-Enterologica Belgica, 卷 54, 編號 5-6, 01.12.1991, p. 328-335.

研究成果: 雜誌貢獻文章

Hu, OYP, Pao, LH, Chung, PH & Tang, HS 1991, 'Pharmacokinetic properties of ranitidine in Chinese people', Acta Gastro-Enterologica Belgica, 卷 54, 編號 5-6, 頁 328-335.
Hu OYP, Pao LH, Chung PH, Tang HS. Pharmacokinetic properties of ranitidine in Chinese people. Acta Gastro-Enterologica Belgica. 1991 12月 1;54(5-6):328-335.
Hu, O. Y.P. ; Pao, L. H. ; Chung, P. H. ; Tang, H. S. / Pharmacokinetic properties of ranitidine in Chinese people. 於: Acta Gastro-Enterologica Belgica. 1991 ; 卷 54, 編號 5-6. 頁 328-335.
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