Pharmacokinetic properties of ranitidine in Chinese people

O. Y.P. Hu, L. H. Pao, P. H. Chung, H. S. Tang

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

The pharmacokinetics and relative bioavailability of two different formulated ranitidine tablets were examined in 12 healthy young Chinese males at one week intervals in a randomized crossover design. Both ranitidine plasma and urine concentrations were measured by a sensitive, accurate and specific High Performance Liquid Chromatography method. No bioavailability differences were found between Glaxo's and Veteran's ranitidine products. However, larger apparent volume of distribution, higher total oral clearance and higher non-renal clearance were observed in Chinese. Further studies are needed to elucidate a higher rantidine dosage may be required for Chinese to achieve the desired plasma level.
原文英語
頁(從 - 到)328-335
頁數8
期刊Acta Gastro-Enterologica Belgica
54
發行號5-6
出版狀態已發佈 - 十二月 1 1991
對外發佈

ASJC Scopus subject areas

  • 消化內科

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