Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix

Lih Chi Chen, Yu Fang Chen, Mei Huei Chou, Ming Fang Lin, Ling Ling Yang, Kun Ying Yen

研究成果: 雜誌貢獻文章同行評審

25 引文 斯高帕斯(Scopus)

摘要

The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in T max indicated that simultaneous oral administration of PR contributed to more rapid absorption of CBZ. It is suggested that the faster absorption of CBZ might lead to the rapid onset of its clinical effect. There were no significant differences in maximum concentration (C max), area under the plasma concentration-time curve (AUC), half-life (t 1/2), mean residence time (MRT), clearance/bioavailability (CL/F), and apparent volume of distribution/bioavailability (V d/F) of CBZ between the two groups, showing that PR did not significantly affect the absorption extent, distribution, metabolism, and elimination of CBZ. A significant decrease in protein binding rate was found when CBZ was coadministered with PR. Further studies are in progress to clarify the clinical significance and the mechanism underlying the effects of PR on the protein binding of CBZ observed in the present study.
原文英語
頁(從 - 到)532-535
頁數4
期刊Biological and Pharmaceutical Bulletin
25
發行號4
DOIs
出版狀態已發佈 - 四月 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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