Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: A cross-sectional study

Rajendra Prasad Janapatla, Mei Hua Hsu, Chyi Liang Chen, Sung Hsi Wei, Ming Jia Yu, Lin Hui Su, Tzou Yien Lin, Cheng Hsun Chiu

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 μg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific IgG could persist above 0.35 μg/mL longer (≥5 years) in the catch-up group than in the 2+1 and 3+1 immunisation groups. 14.5% of the carriage isolates belonged to PCV13 serotypes; statistical analysis revealed that a high serum IgG level (>10.96 μg/mL) will be required to eliminate the point-prevalence nasopharyngeal carriage of serotype 19A.

原文英語
頁(從 - 到)689-692
頁數4
期刊Thorax
75
發行號8
DOIs
出版狀態已發佈 - 8月 1 2020
對外發佈

ASJC Scopus subject areas

  • 肺和呼吸系統醫學

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