Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy

T. I. Lee, Y. H. Kao, Y. C. Chen, J. H. Huang, F. C. Hsiao, Y. J. Chen

研究成果: 雜誌貢獻文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). Chronic inflammation and derangement of myocardial energy and lipid homeostasis are common features of DM. The transcription factors of peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily, which are important in regulating energy and lipid homeostasis. There are three PPAR isoforms, α, γ, and δ, and their roles have been increasingly recognized to be important in CVD. These three isoforms are expressed in the heart and play pivotal roles in myocardial lipid metabolism, as well as glucose and energy homeostasis, and contribute to extra metabolic roles with effects on inflammation and oxidative stress. Moreover, regulation of PPARs may have significant effects on cardiac electrical activity and arrhythmogenesis. This review describes the roles of PPARs and their agonists in DM cardiomyopathy, inflammation, and cardiac electrophysiology.
原文英語
頁(從 - 到)330-339
頁數10
期刊Diabetes Research and Clinical Practice
100
發行號3
DOIs
出版狀態已發佈 - 六月 2013

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

指紋 深入研究「Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy」主題。共同形成了獨特的指紋。

引用此