Peritoneal natural killer cytotoxicity and CD25+CD3+ lymphocyte subpopulation are decreased in women with stage III-IV endometriosis

Hong Nerng Ho, Kuang Han Chao, Hsin Fu Chen, Ming Yih Wu, Yu Shih Yang, Tzu Yao Lee

研究成果: 雜誌貢獻文章同行評審

129 引文 斯高帕斯(Scopus)

摘要

We examined the lymphocytes of peripheral blood (PB) and peritoneal fluid (PF) of women with or without endometriosis to investigate the alteration of cytotoxic activity of natural killer (NK) cells and activation of T cells in the peritoneal cavity of women with endometriosis. A total 16 control women and 14 patients with stage III-IV endometriosis were selected on the basis of laparoscopic examination in National Taiwan University Hospital. The lymphocyte subpopulations (B cell, NK cell and T cell), including T-cell activation markers (CD69, CD25, HLADR), in PB and PF were analysed by dual-colour flow cytometry. The NK cytotoxicity of PB and PF mononuclear cells was evaluated by 51Cr release assay. There was significant decrease of NK cytotoxicity and CD25+CD3+lymphocyte subpopulation in PF of women with endometriosis compared with those without endometriosis. However, there was no difference in the proportion of NK cells in both PB and PF between women with and without endometriosis. Therefore, the decreased NK cytotoxicity PF of women with endometriosis was due to the functional defect, but not quantitative defect, of NK cells. The concomitant reduction of activated T cells in women with endometriosis might suggest its possible role in the defect of NK cytotoxicity.
原文英語
頁(從 - 到)2671-2675
頁數5
期刊Human Reproduction
10
發行號10
DOIs
出版狀態已發佈 - 1月 1 1995
對外發佈

ASJC Scopus subject areas

  • 生殖醫學
  • 婦產科

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