Peritoneal interleukin-10 increases with decrease in activated CD4+ T lymphocytes in women with endometriosis

Hong Nerng Ho, Ming Yih Wu, Kuang Han Chao, Chin Der Chen, Shee Uan Chen, Yu Shih Yang

研究成果: 雜誌貢獻文章同行評審

87 引文 斯高帕斯(Scopus)

摘要

This study was performed to determine whether peritoneal T cells are suppressed in the CD4+ or CD8+ T cell subpopulation and whether they are Th1 or Th2 predominant in women with endometriosis. Immune cells in the peritoneal fluid (PF) were obtained from women undergoing laparoscopy for endometriosis or tubal ligation. Three-colour flow cytometry was utilized for immunophenotyping of peritoneal fluid mononuclear cells (PFMC). Concentrations of interleukin (IL)-4, IL-5 and interferon-γ (IFN-γ) produced by PFMC with and without mitogen stimulation and concentrations of IL-10 and IL-12 were measured in PF. The peritoneal T lymphocytes were predominantly of the Th1 type that produced much more IFN-γ but less IL-4 or IL-5 in women with or without endometriosis. The decrease in peritoneal lymphocytes was significant in the HLA-DR+CD4+CD3+ subpopulation and the concentrations of peritoneal IL-10 and IL-12 were significantly elevated in women with early stage endometriosis. There was impaired IL-5 production by PFMC after phytohaemagglutinin stimulation in women with advanced stage endometriosis. We concluded that the activated peritoneal CD4+ Th1 cells from the women with endometriosis were decreased in number. The suppression of these T cells may be due to the elevation of IL-10 and IL-12 in the peritoneal fluid.
原文英語
頁(從 - 到)2528-2533
頁數6
期刊Human Reproduction
12
發行號11
DOIs
出版狀態已發佈 - 一月 1 1997
對外發佈

ASJC Scopus subject areas

  • 生殖醫學
  • 婦產科

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