摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 158-164 |
頁數 | 7 |
期刊 | Brain and Development |
卷 | 35 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 二月 2013 |
指紋
ASJC Scopus subject areas
- Clinical Neurology
- Developmental Neuroscience
- Pediatrics, Perinatology, and Child Health
引用此文
Perfusion status of the stroke-like lesion at the hyperacute stage in MELAS. / Yeh, Hsu Ling; Chen, Yen Kung; Chen, Wei Hung; Wang, Han Cheng; Chiu, Hou Chang; Lien, Li-Ming; Wei, Yau Huei.
於: Brain and Development, 卷 35, 編號 2, 02.2013, p. 158-164.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Perfusion status of the stroke-like lesion at the hyperacute stage in MELAS
AU - Yeh, Hsu Ling
AU - Chen, Yen Kung
AU - Chen, Wei Hung
AU - Wang, Han Cheng
AU - Chiu, Hou Chang
AU - Lien, Li-Ming
AU - Wei, Yau Huei
PY - 2013/2
Y1 - 2013/2
N2 - Hypoperfusion on single-photon emission computed tomography (SPECT) of the stroke-like lesion (SLL) at the hyperacute stage of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) is considered to be a supportive evidence of the mitochondrial angiopathy theory. Our objectives were to examine whether other neuroimages, especially transcranial color-coded sonography (TCCS), done at the hyperacute stage of stroke-like episode (SLE) is consistent with hypoperfusion of the SLL. We reviewed the magnetic resonance imaging (MRI), SPECT, cerebral angiography, and TCCS of a patient with MELAS syndrome, all of which were performed at the hyperacute stage of one SLE. MRI on the 1st day post SLE showed right temporoparietal lesion with vasogenic edema. SPECT on the 2nd day showed focal decreased uptake of technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) in the same region, but cerebral angiography and TCCS on the 3rd day showed increased regional cerebral blood flow (rCBF) and distal arteriole dilation in the same region. TCCS can delineate increased rCBF of the SLL at the hyperacute stage of SLE. We propose that the discrepancy between the decreased 99mTc-HMPAO uptake and increased rCBF might be caused by mitochondrial dysfunction. The phenomenon of "hypoperfusion" on SPECT might be caused by cell dysfunction but not decreased rCBF. We suggest that SPECT can be complemented by angiography and TCCS in future studies to delineate the perfusion status of SLLs.
AB - Hypoperfusion on single-photon emission computed tomography (SPECT) of the stroke-like lesion (SLL) at the hyperacute stage of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) is considered to be a supportive evidence of the mitochondrial angiopathy theory. Our objectives were to examine whether other neuroimages, especially transcranial color-coded sonography (TCCS), done at the hyperacute stage of stroke-like episode (SLE) is consistent with hypoperfusion of the SLL. We reviewed the magnetic resonance imaging (MRI), SPECT, cerebral angiography, and TCCS of a patient with MELAS syndrome, all of which were performed at the hyperacute stage of one SLE. MRI on the 1st day post SLE showed right temporoparietal lesion with vasogenic edema. SPECT on the 2nd day showed focal decreased uptake of technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) in the same region, but cerebral angiography and TCCS on the 3rd day showed increased regional cerebral blood flow (rCBF) and distal arteriole dilation in the same region. TCCS can delineate increased rCBF of the SLL at the hyperacute stage of SLE. We propose that the discrepancy between the decreased 99mTc-HMPAO uptake and increased rCBF might be caused by mitochondrial dysfunction. The phenomenon of "hypoperfusion" on SPECT might be caused by cell dysfunction but not decreased rCBF. We suggest that SPECT can be complemented by angiography and TCCS in future studies to delineate the perfusion status of SLLs.
KW - Cerebral blood flow
KW - MELAS
KW - SPECT
KW - TCCS
UR - http://www.scopus.com/inward/record.url?scp=84872418848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872418848&partnerID=8YFLogxK
U2 - 10.1016/j.braindev.2012.03.017
DO - 10.1016/j.braindev.2012.03.017
M3 - Article
C2 - 22516515
AN - SCOPUS:84872418848
VL - 35
SP - 158
EP - 164
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 2
ER -