Penicillin in Infants Weighing Two Kilograms or Less with Early-Onset Group B Streptococcal Disease

Suma P. Pyati, Rosita S. Pildes, Norman M. Jacobs, Rajam S. Ramamurthy, Tsu F. Yeh, Devyani S. Raval, Lawrence D. Lilien, P. Amma, William I. Metzger

研究成果: 雜誌貢獻文章同行評審

98 引文 斯高帕斯(Scopus)

摘要

We studied the effect of penicillin on early-onset Group B streptococcal disease over a 52-month period in neonates who were at high risk of infection. Shortly after birth, 1187 neonates weighing 2000 g or less had blood samples taken for cultures and were randomized into an early-treatment group (given intramuscular penicillin G within 60 minutes of birth) or a control group. The incidence of early-onset disease was 20 per 1000 live births (24 of 1187); the number of infants in the early-treatment group who had disease (10 of 589) was similar to that in the control group (14 of 598). The fatality rates were similar in both groups (6 of 10 vs. 8 of 14). Cultures from blood obtained within one hour of birth were positive in 21 of the 24 infants with disease; 22 of the 24 were symptomatic within four hours of birth. Thus, infection was well established before the first hour of postnatal life. At autopsy, gram-positive cocci were seen in lung sections of four infants in whom cultures of blood obtained after treatment had been sterile; this indicates that giving routine antibiotic therapy before culture samples are obtained can obscure bacteriologic diagnosis. We conclude that penicillin given at birth to neonates weighing 2000 g or less does not prevent early-onset streptococcal disease or reduce excess mortality associated with disease. (N Engl J Med 1983; 308:1383–9.) GROUP B streptococcal disease continues to be one of the most common infectious causes of morbidity and mortality in the neonatal period.1 2 3 4 The incidence of early-onset disease ranges from 1 to 4 per 1000 live births.5 The incidence of the disease and its fatality rate are higher in smaller premature infants than in larger infants.6 7 8 Efforts to prevent neonatal disease by eradicating the carrier state during pregnancy have been unsuccessful.9,10 A reduction of colonization in the neonate during the first three days of postnatal life can be achieved by intravenous administration of antibiotics during labor, but reduction of the incidence.

原文英語
頁(從 - 到)1383-1389
頁數7
期刊New England Journal of Medicine
308
發行號23
DOIs
出版狀態已發佈 - 六月 9 1983
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Penicillin in Infants Weighing Two Kilograms or Less with Early-Onset Group B Streptococcal Disease」主題。共同形成了獨特的指紋。

引用此