PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography

Si-Han Wu, Chien Yuan Lin, Yann Hung, Wei Chen, Chen Chang, Chung Yuan Mou

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

A novel magnetic resonance (MR) angiographic method, 3DΔR2-mMRA (three dimensional and ΔR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-Fe 3O 4@SiO 2-PEG where multiple Fe 3O 4 nanocrystals are encapsulated in a thin silica shell to enhance the T 2-relaxivity (r 2 = 342.8 mM -1 s -1) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-Fe 3O 4@SiO 2-PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained.

原文英語
頁(從 - 到)81-88
頁數8
期刊Journal of Biomedical Materials Research - Part B Applied Biomaterials
99 B
發行號1
DOIs
出版狀態已發佈 - 10月 2011
對外發佈

ASJC Scopus subject areas

  • 生物醫學工程
  • 生物材料

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