Patient-derived induced pluripotent stem cells for models of cancer and cancer stem cell research

Hsiao Mei Chao, Edward Chern

研究成果: 雜誌貢獻回顧型文獻同行評審

12 引文 斯高帕斯(Scopus)

摘要

Induced pluripotent stem cells (iPSCs) are embryonic stem cell-like cells reprogrammed from somatic cells by four transcription factors, OCT4, SOX2, KLF4 and c-MYC. iPSCs derived from cancer cells (cancer-iPSCs) could be a novel strategy for studying cancer. During cancer cell reprogramming, the epigenetic status of the cancer cell may be altered, such that it acquires stemness and pluripotency. The cellular behavior of the reprogrammed cells exhibits dynamic changes during the different stages of reprogramming. The cells may acquire the properties of cancer stem cells (CSCs) during the process of reprogramming, and lose their carcinogenic properties during reprogramming into a cancer-iPSCs. Differentiation of cancer-iPSCs by teratoma formation or organoid culturing could mimic the process of tumorigenesis. Some of the molecular mechanisms associated with cancer progression could be elucidated using the cancer-iPSC model. Furthermore, cancer-iPSCs could be expanded in culture system or bioreactors, and serve as cell sources for research, and as personal disease models for therapy and drug screening. This article introduces cancer studies that used the cell reprogramming strategy.

原文英語
頁(從 - 到)1046-1057
頁數12
期刊Journal of the Formosan Medical Association
117
發行號12
DOIs
出版狀態已發佈 - 十二月 1 2018

ASJC Scopus subject areas

  • 醫藥 (全部)

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