摘要

Emerging risk factors for tuberculosis (TB) infection, such as air pollution, play a significant role at both the individual and population levels. However, the association between air pollution and TB remains unclear. The objective of this study was to examine the associa- tion between outdoor air pollution and sputum culture conversion in TB patients. In the present study, 389 subjects were recruited from a hospital in Taiwan from 2010 to 2012: 144 controls with non-TB-related pulmonary diseases with negative sputum cultures and 245 culture-positive TB subjects. We observed that a 1 μg/m3 increase in particulate matter of ≤10 μm in aerodynamic diameter (PM10) resulted in 4% higher odds of TB (odds ratio =1.04, 95% confidence interval=1.01-1.08, P10 (R2=0.94, P10. In subjects with TB-positive cultures, annual exposure to ≥50 μg/m3 PM10 was associated with an increase in the time required for sputum culture conversion (hazard ratio =1.28, 95% confidence interval: 1.07-1.84, P3 PM10 may prolong the sputum culture conversion of TB patients with sputum-positive cultures.
原文英語
頁(從 - 到)41-46
頁數6
期刊Therapeutics and Clinical Risk Management
12
DOIs
出版狀態已發佈 - 一月 6 2016

指紋

Particulate Matter
Sputum
Air pollution
contagious disease
Tuberculosis
Air Pollution
air pollution
Pulmonary diseases
Hazards
Aerodynamics
confidence
Confidence Intervals
demographic situation
Taiwan
Lung Diseases
Odds Ratio
Disease
Infection
Population

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Safety Research
  • Chemical Health and Safety

引用此文

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title = "Particulate matter is associated with sputum culture conversion in patients with culture-positive tuberculosis",
abstract = "Emerging risk factors for tuberculosis (TB) infection, such as air pollution, play a significant role at both the individual and population levels. However, the association between air pollution and TB remains unclear. The objective of this study was to examine the associa- tion between outdoor air pollution and sputum culture conversion in TB patients. In the present study, 389 subjects were recruited from a hospital in Taiwan from 2010 to 2012: 144 controls with non-TB-related pulmonary diseases with negative sputum cultures and 245 culture-positive TB subjects. We observed that a 1 μg/m3 increase in particulate matter of ≤10 μm in aerodynamic diameter (PM10) resulted in 4{\%} higher odds of TB (odds ratio =1.04, 95{\%} confidence interval=1.01-1.08, P10 (R2=0.94, P10. In subjects with TB-positive cultures, annual exposure to ≥50 μg/m3 PM10 was associated with an increase in the time required for sputum culture conversion (hazard ratio =1.28, 95{\%} confidence interval: 1.07-1.84, P3 PM10 may prolong the sputum culture conversion of TB patients with sputum-positive cultures.",
keywords = "Air pollution, Chest X-ray, Particulate matter, Sputum culture, Tuberculosis",
author = "Chen, {Kuan Yuan} and Chuang, {Kai Jen} and Liu, {Hui Chiao} and Lee, {Kang Yun} and Feng, {Po Hao} and Su, {Chien Ling} and Lin, {Chii Lan} and Lee, {Chun Nin} and Chuang, {Hsiao Chi}",
year = "2016",
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pages = "41--46",
journal = "Therapeutics and Clinical Risk Management",
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AU - Chen, Kuan Yuan

AU - Chuang, Kai Jen

AU - Liu, Hui Chiao

AU - Lee, Kang Yun

AU - Feng, Po Hao

AU - Su, Chien Ling

AU - Lin, Chii Lan

AU - Lee, Chun Nin

AU - Chuang, Hsiao Chi

PY - 2016/1/6

Y1 - 2016/1/6

N2 - Emerging risk factors for tuberculosis (TB) infection, such as air pollution, play a significant role at both the individual and population levels. However, the association between air pollution and TB remains unclear. The objective of this study was to examine the associa- tion between outdoor air pollution and sputum culture conversion in TB patients. In the present study, 389 subjects were recruited from a hospital in Taiwan from 2010 to 2012: 144 controls with non-TB-related pulmonary diseases with negative sputum cultures and 245 culture-positive TB subjects. We observed that a 1 μg/m3 increase in particulate matter of ≤10 μm in aerodynamic diameter (PM10) resulted in 4% higher odds of TB (odds ratio =1.04, 95% confidence interval=1.01-1.08, P10 (R2=0.94, P10. In subjects with TB-positive cultures, annual exposure to ≥50 μg/m3 PM10 was associated with an increase in the time required for sputum culture conversion (hazard ratio =1.28, 95% confidence interval: 1.07-1.84, P3 PM10 may prolong the sputum culture conversion of TB patients with sputum-positive cultures.

AB - Emerging risk factors for tuberculosis (TB) infection, such as air pollution, play a significant role at both the individual and population levels. However, the association between air pollution and TB remains unclear. The objective of this study was to examine the associa- tion between outdoor air pollution and sputum culture conversion in TB patients. In the present study, 389 subjects were recruited from a hospital in Taiwan from 2010 to 2012: 144 controls with non-TB-related pulmonary diseases with negative sputum cultures and 245 culture-positive TB subjects. We observed that a 1 μg/m3 increase in particulate matter of ≤10 μm in aerodynamic diameter (PM10) resulted in 4% higher odds of TB (odds ratio =1.04, 95% confidence interval=1.01-1.08, P10 (R2=0.94, P10. In subjects with TB-positive cultures, annual exposure to ≥50 μg/m3 PM10 was associated with an increase in the time required for sputum culture conversion (hazard ratio =1.28, 95% confidence interval: 1.07-1.84, P3 PM10 may prolong the sputum culture conversion of TB patients with sputum-positive cultures.

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