Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study

Ya-Ping Huang, Li-Sheng Chen, Ming-Fang Yen, Ching-Yuan Fann, Yueh-Hsia Chiu, Hsiu-Hsi Chen, Shin-Liang Pan

研究成果: 雜誌貢獻文章

206 引文 (Scopus)

摘要

OBJECTIVE: The risk of stroke in patients with Parkinson's disease (PD) remains controversial. The purpose of this population-based propensity score-matched longitudinal follow-up study was to determine whether there is an increased risk of ischemic stroke after PD. METHODS: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 2204 patients with at least two ambulatory visits with the principal diagnosis of PD in 2001 was enrolled in the PD group. The non- PD group consisted of 2204, propensity score-matched subjects without PD. The ischemic stroke-free survival rates of the two groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of PD on the occurrence of ischemic stroke. RESULTS: During the three-year follow-up period, 328 subjects in the PD group and 156 subjects in the non-PD group developed ischemic stroke. The ischemic stroke-free survival rate of the PD group was significantly lower than that of the non-PD group (P<0.0001). The hazard ratio (HR) of stroke for the PD group was 2.37 (95% confidence interval [CI], 1.92 to 2.93, P<0.0001) compared to the non- PD group. CONCLUSIONS: This study shows a significantly increased risk of ischemic stroke in PD patients. Further studies are required to investigate the underlying mechanism.
原文英語
頁(從 - 到)e68314
期刊PLoS One
8
發行號9
DOIs
出版狀態已發佈 - 2013

指紋

Propensity Score
Parkinson disease
stroke
Parkinson Disease
Stroke
Population
Survival Rate
survival rate
Logistic Models
Hazards
socioeconomic status
Social Class
Comorbidity
confidence interval
Logistics

引用此文

Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study. / Huang, Ya-Ping; Chen, Li-Sheng; Yen, Ming-Fang; Fann, Ching-Yuan; Chiu, Yueh-Hsia; Chen, Hsiu-Hsi; Pan, Shin-Liang.

於: PLoS One, 卷 8, 編號 9, 2013, p. e68314.

研究成果: 雜誌貢獻文章

Huang, Ya-Ping ; Chen, Li-Sheng ; Yen, Ming-Fang ; Fann, Ching-Yuan ; Chiu, Yueh-Hsia ; Chen, Hsiu-Hsi ; Pan, Shin-Liang. / Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study. 於: PLoS One. 2013 ; 卷 8, 編號 9. 頁 e68314.
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title = "Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study",
abstract = "OBJECTIVE: The risk of stroke in patients with Parkinson's disease (PD) remains controversial. The purpose of this population-based propensity score-matched longitudinal follow-up study was to determine whether there is an increased risk of ischemic stroke after PD.METHODS: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 2204 patients with at least two ambulatory visits with the principal diagnosis of PD in 2001 was enrolled in the PD group. The non- PD group consisted of 2204, propensity score-matched subjects without PD. The ischemic stroke-free survival rates of the two groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of PD on the occurrence of ischemic stroke.RESULTS: During the three-year follow-up period, 328 subjects in the PD group and 156 subjects in the non-PD group developed ischemic stroke. The ischemic stroke-free survival rate of the PD group was significantly lower than that of the non-PD group (P<0.0001). The hazard ratio (HR) of stroke for the PD group was 2.37 (95{\%} confidence interval [CI], 1.92 to 2.93, P<0.0001) compared to the non- PD group.CONCLUSIONS: This study shows a significantly increased risk of ischemic stroke in PD patients. Further studies are required to investigate the underlying mechanism.",
keywords = "Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Logistic Models, Male, Middle Aged, Parkinson Disease, Propensity Score, Prospective Studies, Stroke, Journal Article, Research Support, Non-U.S. Gov't",
author = "Ya-Ping Huang and Li-Sheng Chen and Ming-Fang Yen and Ching-Yuan Fann and Yueh-Hsia Chiu and Hsiu-Hsi Chen and Shin-Liang Pan",
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T1 - Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study

AU - Huang, Ya-Ping

AU - Chen, Li-Sheng

AU - Yen, Ming-Fang

AU - Fann, Ching-Yuan

AU - Chiu, Yueh-Hsia

AU - Chen, Hsiu-Hsi

AU - Pan, Shin-Liang

PY - 2013

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N2 - OBJECTIVE: The risk of stroke in patients with Parkinson's disease (PD) remains controversial. The purpose of this population-based propensity score-matched longitudinal follow-up study was to determine whether there is an increased risk of ischemic stroke after PD.METHODS: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 2204 patients with at least two ambulatory visits with the principal diagnosis of PD in 2001 was enrolled in the PD group. The non- PD group consisted of 2204, propensity score-matched subjects without PD. The ischemic stroke-free survival rates of the two groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of PD on the occurrence of ischemic stroke.RESULTS: During the three-year follow-up period, 328 subjects in the PD group and 156 subjects in the non-PD group developed ischemic stroke. The ischemic stroke-free survival rate of the PD group was significantly lower than that of the non-PD group (P<0.0001). The hazard ratio (HR) of stroke for the PD group was 2.37 (95% confidence interval [CI], 1.92 to 2.93, P<0.0001) compared to the non- PD group.CONCLUSIONS: This study shows a significantly increased risk of ischemic stroke in PD patients. Further studies are required to investigate the underlying mechanism.

AB - OBJECTIVE: The risk of stroke in patients with Parkinson's disease (PD) remains controversial. The purpose of this population-based propensity score-matched longitudinal follow-up study was to determine whether there is an increased risk of ischemic stroke after PD.METHODS: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 2204 patients with at least two ambulatory visits with the principal diagnosis of PD in 2001 was enrolled in the PD group. The non- PD group consisted of 2204, propensity score-matched subjects without PD. The ischemic stroke-free survival rates of the two groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of PD on the occurrence of ischemic stroke.RESULTS: During the three-year follow-up period, 328 subjects in the PD group and 156 subjects in the non-PD group developed ischemic stroke. The ischemic stroke-free survival rate of the PD group was significantly lower than that of the non-PD group (P<0.0001). The hazard ratio (HR) of stroke for the PD group was 2.37 (95% confidence interval [CI], 1.92 to 2.93, P<0.0001) compared to the non- PD group.CONCLUSIONS: This study shows a significantly increased risk of ischemic stroke in PD patients. Further studies are required to investigate the underlying mechanism.

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Parkinson Disease

KW - Propensity Score

KW - Prospective Studies

KW - Stroke

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

UR - https://www.ncbi.nlm.nih.gov/pubmed/24023710

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JO - PLoS One

JF - PLoS One

SN - 1932-6203

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ER -