Pardaxin, an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells

Tsui Chin Huang, Jheng Fong Lee, Jyh Yih Chen

研究成果: 雜誌貢獻文章

52 引文 斯高帕斯(Scopus)

摘要

Pardaxin is an antimicrobial peptide (AMP) that was first isolated from secretions of the Red Sea Moses sole. The role of pardaxin in inducing apoptosis for preventing cancer has not yet been investigated. In the present study, we examined the antitumor activity of pardaxin against human fibrosarcoma HT-1080 cells; pardaxin inhibited cell proliferation by inducing apoptosis, as demonstrated by an increase in the externalization of plasma membrane phosphatidylserine and the presence of chromatin condensation. Additionally, pardaxin-treated cells showed elevation of caspase-3/7 activities, disruption of the mitochondrial membrane potential, and accumulation of reactive oxygen species (ROS) production. Inhibition of ROS production and caspase-3/7 activities reduced pardaxin-induced effects. Taken together, these findings suggest that pardaxin may be a potential anticancer agent for selectively inducing apoptosis in cancer cells.
原文英語
頁(從 - 到)1995-2009
頁數15
期刊Marine Drugs
9
發行號10
DOIs
出版狀態已發佈 - 十月 2011
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Drug Discovery

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