Paraurethral striated muscular structures and pelvic floor muscles contribute to resting urethral closure pressure in rats

Hung Yen Chin, Kuan Cheng Lin, Chin Jung Wang, Chi Hsin Chiang, Hann Chorng Kuo

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Introduction and hypothesis: We investigated physiological functions of the extraordinary muscular structure in the paraurethral area with pelvic floor muscle and the impact of these muscular structures on the resting maximal urethral closure pressure (MUCP) in rats. Methods: Sixteen female Wister rats were divided into four groups: Groups I and II rats received 5 and 2.5 IU botulinum toxin A (BoNT-A), respectively, injected into the bilateral paraurethral striated muscles. Group III rats received 2.5 IU BoNT-A injected into the bilateral pelvic floor muscles, and group IV rats received 2.5 IU BoNT-A injected into the unilateral pelvic floor muscles. Measurements of MUCP were made at different time points after BoNT-A injection. Results All groups showed a rapid reduction in average MUCP by 70-80 % after BoNT-A injection, regardless of injection site or side. Conclusions: Paraurethral striated muscular structures and the pelvic floor muscles possess the function of maintaining resting MUCP in rats.
原文英語
頁(從 - 到)1631-1636
頁數6
期刊International Urogynecology Journal
23
發行號11
DOIs
出版狀態已發佈 - 一月 1 2012
對外發佈

Keywords

  • Botulinum toxin
  • Maximal urethral closure pressure
  • Pelvic floor
  • Striated muscle
  • Urethra
  • Urethral rhabdosphincter
  • Urethral sphincter

ASJC Scopus subject areas

  • 婦產科
  • 泌尿科學

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