Papaverine and prostaglandin E1 gel applications for impotence

H. S. Chiang, Y. H. Kao, M. T. Sheu

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

The transdermal permeability of papaverine and prostaglandin E1 (PGE1) could be determined in vitro. A chemical scheme of passive delivery or with enhancer, as well as a physical iontophoretic transdermal delivery system were designed in the laboratory. Clinically, up to 20% papaverine base gel and 500 μg PGE1 were applied onto the genital area without any side effect. Only vascular response could be detected by ultrasound. However, immediate erection could not be obtained at the present dosage. Further research on the combination of skin absorption enhancers, the different chemical derivatives of PGE1 or a different administration route is warranted.

原文英語
頁(從 - 到)767-769
頁數3
期刊Annals of the Academy of Medicine Singapore
24
發行號5
出版狀態已發佈 - 1995

ASJC Scopus subject areas

  • 醫藥 (全部)

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