Panel biomarkers associated with cancer invasion and prognostic prediction for head-neck cancer

Yin Ju Chen, Joseph T. Chang, Guo Rung You, Chun Yu Huang, Kang Hsing Fan, Ann Joy Cheng

研究成果: 雜誌貢獻文章同行評審

摘要

Aim: Cell invasion leading to metastasis is a major cause of treatment failure in head-neck cancers (HNCs). Identifying prognostic molecules associated with invasiveness is imperative for clinical applications. Materials & methods: A systemic approach was used to globally survey invasion-related genes, including transcriptomic profiling, pathway analysis, data mining and prognostic assessment using TCGA-HNSC dataset. Results: Six functional pathways and six hub molecules (LAMA3, LAMC2, THBS1, IGF1R, PDGFB and TGFβ1) were identified that significantly contributed to cell invasion, leading to poor survival in HNC patients. Combinations of multiple biomarkers substantially increased the probability of accurately predicting prognosis. Conclusion: Our six defined invasion-related molecules may be used as a panel signature in precision medicine for prognostic indicators or molecular therapeutic targets for HNC.

原文英語
頁(從 - 到)861-877
頁數17
期刊Biomarkers in Medicine
15
發行號11
DOIs
出版狀態已發佈 - 八月 2021

ASJC Scopus subject areas

  • 藥物發現
  • 臨床生物化學
  • 生物化學(醫學)

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