The levels of N-terminal pro-Brain Natriuretic Peptide (NT-proBNP)are elevated in heart failure and other triggers of ventricular dysfunction,such as myocardial ischemia. Increased plasma CRP is associated with higher risks of future cardiovascular events. The effects of combination of plasma NT pro-BNP and CRP on the long term prognosis of CAD patientsare still unclear.We recruited 424 patients with angiographically-proven CAD. Cutoff values for plasma NT-proBNP and CRP are 682 pg/mL and 3.0mg/L,respectively. MACEs (CV mortality, MI and stroke) and TVR were recorded during the 8-26 months follow-up. Results: see figures. Cox regression showed the independent predictors for MACEs are:diabetes (HR: 2.0, 95% CI: 1.0, 3.7, p--0.04), NT-proBNP (HR: 5.4, 95%CI: 2.9, 10.0, p<0.001) and CRP (HR: 2.1, 95% CI: 1.1, 4.1, p--0.03); forTVR: diabetes (HR :2.2, 95% CI: 1.2, 3.9, p--0.01), NT-proBNP (HR :3.0,95% CI:I.8, 5.0, p<0.001) and CRP (HR: 1.8, 95% CI: 1.1, 2.8, p--0.02).Conclusion: The combination of plasma NT-proBNP and CRP is a strong predictor of MACEs and TVR in patients with coronary artery disease.
|出版狀態||已發佈 - 12月 31 2004|