Oxygen-implanted induced formation of oxide layer enhances blood compatibility on titanium for biomedical applications

Wei Chiang Hung, Fang Mo Chang, Tzu Sen Yang, Keng Liang Ou, Che Tong Lin, Pei Wen Peng

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Titanium dioxide (TiO2) layers were prepared on a Ti substrate by using oxygen plasma immersion ion implantation (oxygen PIII). The surface chemical states, structure, and morphology of the layers were studied using X-ray photoelectron spectroscopy, X-ray diffraction, Raman microscopy, atomic force microscopy and scanning electron microscope. The mechanical properties, such as the Young's modulus and hardness, of the layers were investigated using nanoindentation testing. The Ti4 + chemical state was determined to be present on oxygen-PIII-treated surfaces, which consisted of nanocrystalline TiO2 with a rutile structure. Compared with Ti substrates, the oxygen-PIII-treated surfaces exhibited decreased Young's moduli and hardness. Parameters indicating the blood compatibility of the oxygen-PIII-treated surfaces, including the clotting time and platelet adhesion and activation, were studied in vitro. Clotting time assays indicated that the clotting time of oxygen-PIII-treated surfaces was longer than that of the Ti substrate, which was associated with decreased fibrinogen adsorption. In conclusion, the surface characteristics and the blood compatibility of Ti implants can be modified and improved using oxygen PIII.
原文英語
頁(從 - 到)523-529
頁數7
期刊Materials Science and Engineering C
68
DOIs
出版狀態已發佈 - 十一月 1 2016

指紋

Titanium
Oxides
compatibility
blood
Blood
titanium
clotting
Oxygen
oxides
oxygen
oxygen plasma
Ion implantation
submerging
ion implantation
modulus of elasticity
Substrates
hardness
Elastic moduli
Hardness
Plasmas

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

引用此文

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title = "Oxygen-implanted induced formation of oxide layer enhances blood compatibility on titanium for biomedical applications",
abstract = "Titanium dioxide (TiO2) layers were prepared on a Ti substrate by using oxygen plasma immersion ion implantation (oxygen PIII). The surface chemical states, structure, and morphology of the layers were studied using X-ray photoelectron spectroscopy, X-ray diffraction, Raman microscopy, atomic force microscopy and scanning electron microscope. The mechanical properties, such as the Young's modulus and hardness, of the layers were investigated using nanoindentation testing. The Ti4 + chemical state was determined to be present on oxygen-PIII-treated surfaces, which consisted of nanocrystalline TiO2 with a rutile structure. Compared with Ti substrates, the oxygen-PIII-treated surfaces exhibited decreased Young's moduli and hardness. Parameters indicating the blood compatibility of the oxygen-PIII-treated surfaces, including the clotting time and platelet adhesion and activation, were studied in vitro. Clotting time assays indicated that the clotting time of oxygen-PIII-treated surfaces was longer than that of the Ti substrate, which was associated with decreased fibrinogen adsorption. In conclusion, the surface characteristics and the blood compatibility of Ti implants can be modified and improved using oxygen PIII.",
keywords = "Clotting time, Oxygen plasma-immersion ion implantation (oxygen PIII), Platelet activation, Titanium",
author = "Hung, {Wei Chiang} and Chang, {Fang Mo} and Yang, {Tzu Sen} and Ou, {Keng Liang} and Lin, {Che Tong} and Peng, {Pei Wen}",
year = "2016",
month = "11",
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doi = "10.1016/j.msec.2016.06.024",
language = "English",
volume = "68",
pages = "523--529",
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T1 - Oxygen-implanted induced formation of oxide layer enhances blood compatibility on titanium for biomedical applications

AU - Hung, Wei Chiang

AU - Chang, Fang Mo

AU - Yang, Tzu Sen

AU - Ou, Keng Liang

AU - Lin, Che Tong

AU - Peng, Pei Wen

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Titanium dioxide (TiO2) layers were prepared on a Ti substrate by using oxygen plasma immersion ion implantation (oxygen PIII). The surface chemical states, structure, and morphology of the layers were studied using X-ray photoelectron spectroscopy, X-ray diffraction, Raman microscopy, atomic force microscopy and scanning electron microscope. The mechanical properties, such as the Young's modulus and hardness, of the layers were investigated using nanoindentation testing. The Ti4 + chemical state was determined to be present on oxygen-PIII-treated surfaces, which consisted of nanocrystalline TiO2 with a rutile structure. Compared with Ti substrates, the oxygen-PIII-treated surfaces exhibited decreased Young's moduli and hardness. Parameters indicating the blood compatibility of the oxygen-PIII-treated surfaces, including the clotting time and platelet adhesion and activation, were studied in vitro. Clotting time assays indicated that the clotting time of oxygen-PIII-treated surfaces was longer than that of the Ti substrate, which was associated with decreased fibrinogen adsorption. In conclusion, the surface characteristics and the blood compatibility of Ti implants can be modified and improved using oxygen PIII.

AB - Titanium dioxide (TiO2) layers were prepared on a Ti substrate by using oxygen plasma immersion ion implantation (oxygen PIII). The surface chemical states, structure, and morphology of the layers were studied using X-ray photoelectron spectroscopy, X-ray diffraction, Raman microscopy, atomic force microscopy and scanning electron microscope. The mechanical properties, such as the Young's modulus and hardness, of the layers were investigated using nanoindentation testing. The Ti4 + chemical state was determined to be present on oxygen-PIII-treated surfaces, which consisted of nanocrystalline TiO2 with a rutile structure. Compared with Ti substrates, the oxygen-PIII-treated surfaces exhibited decreased Young's moduli and hardness. Parameters indicating the blood compatibility of the oxygen-PIII-treated surfaces, including the clotting time and platelet adhesion and activation, were studied in vitro. Clotting time assays indicated that the clotting time of oxygen-PIII-treated surfaces was longer than that of the Ti substrate, which was associated with decreased fibrinogen adsorption. In conclusion, the surface characteristics and the blood compatibility of Ti implants can be modified and improved using oxygen PIII.

KW - Clotting time

KW - Oxygen plasma-immersion ion implantation (oxygen PIII)

KW - Platelet activation

KW - Titanium

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