Oxidative stress on pulmonary vein and left atrium arrhythmogenesis

Yung Kuo Lin, Feng Zhi Lin, Yao Chang Chen, Chen Chuan Cheng, Cheng I. Lin, Yi Jen Chen, Shih Ann Chen

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

Background: Oxidative stress and pulmonary veins (PVs) play critical roles in the pathophysiology of atrial fibrillation. The purpose of the present study was to investigate whether oxidative stress and antioxidant agents can change the electrophysiological characteristics of the left atrium (LA) and PVs.&Methods and Results: Conventional microelectrodes were used to record the action potentials (APs) in isolated rabbit PV and LA specimens before and after H2O2 administration with or without ascorbic acid or N-mercaptopro-pionylglycine (N-MPG, a free radical ·OH scavenger). H2O2 (0.02 and 0.2mmol/L) decreased the PV spontaneous rates from 2.0±0.1 Hz to 1.6±0.1 Hz, and 1.7±0.1 Hz (n=10, P

原文英語
頁(從 - 到)1547-1556
頁數10
期刊Circulation Journal
74
發行號8
DOIs
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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