@article{63b217c88fb14b999f1663f6a5f4aed5,
title = "Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma",
abstract = "Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.",
keywords = "JAK2, Janus kinase, nasopharyngeal carcinoma, prognosis, transcriptome",
author = "He, {Hong Lin} and Lee, {Ying En} and Liang, {Peir In} and Lee, {Sung Wei} and Chen, {Tzu Ju} and Chan, {Ti Chun} and Hsing, {Chung Hsi} and Chang, {I. Wei} and Shiue, {Yow Ling} and Li, {Chien Feng}",
note = "Funding Information: This study was supported by a grant from the Ministry of Health and Welfare (MOHW103-TD-B-111-05) and E-Da Hospital (EDAHP105012). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",
year = "2016",
month = aug,
doi = "10.2217/fon-2016-0025",
language = "English",
volume = "12",
pages = "1887--1896",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "16",
}
