Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers

Xiaochen Wang, Xiyong Liu, Angela Ying Jian Li, Lirong Chen, Lily Lai, Her Helen Lin, Shuya Hu, Lifang Yao, Jiaping Peng, Sofia Loera, Lijun Xue, Bingsen Zhou, Lun Zhou, Shu Zheng, Peiguo Chu, Suzhan Zhang, David Kong Ann, Yun Yen

研究成果: 雜誌貢獻文章

112 引文 (Scopus)

摘要

Purpose: This study aims to address the hypothesis that the high-mobility group A2 (HMGA2), an oncofetal protein, relates to survivability and serves as a prognostic biomarker for colorectal cancer (CRC). Experimental Design: This is a retroprospective multiple center study. The HMGA2 expression level was determined by performing immunohistochemistry on surgical tissue samples of 89 CRCs from a training set and 191 CRCs from a validation set. The Kaplan-Meier analysis and COX proportional hazard model were employed to analyze the survivability. Results: Multivariate logistic analysis indicated that the expression of HMGA2 significantly correlates with distant metastasis in training set (odds ratio, OR = 3.53, 95% CI: 1.37-9.70) and validation set (OR = 6.38, 95% CI: 1.47-43.95). Survival analysis revealed that the overexpression of HMGA2 is significantly associated with poor survival of CRC patients (P < 0.05). The adjusted HRs for overall survival were 2.38 (95% CI: 1.30-4.34) and 2.14 (95% CI: 1.21-3.79) in training and validation sets, respectively. Further investigation revealed that HMGA2 delays the clearance of γ-H2AX in HCT-116 and SW480 cells post γ-irradiation, which supports our finding that CRC patients with HMAG2-positive staining in primary tumors had augmented the efficacy of adjuvant radiotherapy (HR = 0.18, 95% CI: 0.04-0.63). Conclusion: Overexpression of HMGA2 is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC. Therefore, HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator for better response of radiotherapy.

原文英語
頁(從 - 到)2570-2580
頁數11
期刊Clinical Cancer Research
17
發行號8
DOIs
出版狀態已發佈 - 四月 15 2011
對外發佈Yes

指紋

varespladib methyl
Colorectal Neoplasms
Neoplasm Metastasis
Survival
Biomarkers
HCT116 Cells
Adjuvant Radiotherapy
Kaplan-Meier Estimate
Survival Analysis
Proportional Hazards Models
Research Design
Radiotherapy
Multivariate Analysis
Survival Rate
Immunohistochemistry
Odds Ratio
Staining and Labeling
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

引用此文

Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers. / Wang, Xiaochen; Liu, Xiyong; Li, Angela Ying Jian; Chen, Lirong; Lai, Lily; Lin, Her Helen; Hu, Shuya; Yao, Lifang; Peng, Jiaping; Loera, Sofia; Xue, Lijun; Zhou, Bingsen; Zhou, Lun; Zheng, Shu; Chu, Peiguo; Zhang, Suzhan; Ann, David Kong; Yen, Yun.

於: Clinical Cancer Research, 卷 17, 編號 8, 15.04.2011, p. 2570-2580.

研究成果: 雜誌貢獻文章

Wang, X, Liu, X, Li, AYJ, Chen, L, Lai, L, Lin, HH, Hu, S, Yao, L, Peng, J, Loera, S, Xue, L, Zhou, B, Zhou, L, Zheng, S, Chu, P, Zhang, S, Ann, DK & Yen, Y 2011, 'Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers', Clinical Cancer Research, 卷 17, 編號 8, 頁 2570-2580. https://doi.org/10.1158/1078-0432.CCR-10-2542
Wang, Xiaochen ; Liu, Xiyong ; Li, Angela Ying Jian ; Chen, Lirong ; Lai, Lily ; Lin, Her Helen ; Hu, Shuya ; Yao, Lifang ; Peng, Jiaping ; Loera, Sofia ; Xue, Lijun ; Zhou, Bingsen ; Zhou, Lun ; Zheng, Shu ; Chu, Peiguo ; Zhang, Suzhan ; Ann, David Kong ; Yen, Yun. / Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers. 於: Clinical Cancer Research. 2011 ; 卷 17, 編號 8. 頁 2570-2580.
@article{aed79162390448b18e200f47d2eb639d,
title = "Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers",
abstract = "Purpose: This study aims to address the hypothesis that the high-mobility group A2 (HMGA2), an oncofetal protein, relates to survivability and serves as a prognostic biomarker for colorectal cancer (CRC). Experimental Design: This is a retroprospective multiple center study. The HMGA2 expression level was determined by performing immunohistochemistry on surgical tissue samples of 89 CRCs from a training set and 191 CRCs from a validation set. The Kaplan-Meier analysis and COX proportional hazard model were employed to analyze the survivability. Results: Multivariate logistic analysis indicated that the expression of HMGA2 significantly correlates with distant metastasis in training set (odds ratio, OR = 3.53, 95{\%} CI: 1.37-9.70) and validation set (OR = 6.38, 95{\%} CI: 1.47-43.95). Survival analysis revealed that the overexpression of HMGA2 is significantly associated with poor survival of CRC patients (P < 0.05). The adjusted HRs for overall survival were 2.38 (95{\%} CI: 1.30-4.34) and 2.14 (95{\%} CI: 1.21-3.79) in training and validation sets, respectively. Further investigation revealed that HMGA2 delays the clearance of γ-H2AX in HCT-116 and SW480 cells post γ-irradiation, which supports our finding that CRC patients with HMAG2-positive staining in primary tumors had augmented the efficacy of adjuvant radiotherapy (HR = 0.18, 95{\%} CI: 0.04-0.63). Conclusion: Overexpression of HMGA2 is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC. Therefore, HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator for better response of radiotherapy.",
author = "Xiaochen Wang and Xiyong Liu and Li, {Angela Ying Jian} and Lirong Chen and Lily Lai and Lin, {Her Helen} and Shuya Hu and Lifang Yao and Jiaping Peng and Sofia Loera and Lijun Xue and Bingsen Zhou and Lun Zhou and Shu Zheng and Peiguo Chu and Suzhan Zhang and Ann, {David Kong} and Yun Yen",
year = "2011",
month = "4",
day = "15",
doi = "10.1158/1078-0432.CCR-10-2542",
language = "English",
volume = "17",
pages = "2570--2580",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "8",

}

TY - JOUR

T1 - Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers

AU - Wang, Xiaochen

AU - Liu, Xiyong

AU - Li, Angela Ying Jian

AU - Chen, Lirong

AU - Lai, Lily

AU - Lin, Her Helen

AU - Hu, Shuya

AU - Yao, Lifang

AU - Peng, Jiaping

AU - Loera, Sofia

AU - Xue, Lijun

AU - Zhou, Bingsen

AU - Zhou, Lun

AU - Zheng, Shu

AU - Chu, Peiguo

AU - Zhang, Suzhan

AU - Ann, David Kong

AU - Yen, Yun

PY - 2011/4/15

Y1 - 2011/4/15

N2 - Purpose: This study aims to address the hypothesis that the high-mobility group A2 (HMGA2), an oncofetal protein, relates to survivability and serves as a prognostic biomarker for colorectal cancer (CRC). Experimental Design: This is a retroprospective multiple center study. The HMGA2 expression level was determined by performing immunohistochemistry on surgical tissue samples of 89 CRCs from a training set and 191 CRCs from a validation set. The Kaplan-Meier analysis and COX proportional hazard model were employed to analyze the survivability. Results: Multivariate logistic analysis indicated that the expression of HMGA2 significantly correlates with distant metastasis in training set (odds ratio, OR = 3.53, 95% CI: 1.37-9.70) and validation set (OR = 6.38, 95% CI: 1.47-43.95). Survival analysis revealed that the overexpression of HMGA2 is significantly associated with poor survival of CRC patients (P < 0.05). The adjusted HRs for overall survival were 2.38 (95% CI: 1.30-4.34) and 2.14 (95% CI: 1.21-3.79) in training and validation sets, respectively. Further investigation revealed that HMGA2 delays the clearance of γ-H2AX in HCT-116 and SW480 cells post γ-irradiation, which supports our finding that CRC patients with HMAG2-positive staining in primary tumors had augmented the efficacy of adjuvant radiotherapy (HR = 0.18, 95% CI: 0.04-0.63). Conclusion: Overexpression of HMGA2 is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC. Therefore, HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator for better response of radiotherapy.

AB - Purpose: This study aims to address the hypothesis that the high-mobility group A2 (HMGA2), an oncofetal protein, relates to survivability and serves as a prognostic biomarker for colorectal cancer (CRC). Experimental Design: This is a retroprospective multiple center study. The HMGA2 expression level was determined by performing immunohistochemistry on surgical tissue samples of 89 CRCs from a training set and 191 CRCs from a validation set. The Kaplan-Meier analysis and COX proportional hazard model were employed to analyze the survivability. Results: Multivariate logistic analysis indicated that the expression of HMGA2 significantly correlates with distant metastasis in training set (odds ratio, OR = 3.53, 95% CI: 1.37-9.70) and validation set (OR = 6.38, 95% CI: 1.47-43.95). Survival analysis revealed that the overexpression of HMGA2 is significantly associated with poor survival of CRC patients (P < 0.05). The adjusted HRs for overall survival were 2.38 (95% CI: 1.30-4.34) and 2.14 (95% CI: 1.21-3.79) in training and validation sets, respectively. Further investigation revealed that HMGA2 delays the clearance of γ-H2AX in HCT-116 and SW480 cells post γ-irradiation, which supports our finding that CRC patients with HMAG2-positive staining in primary tumors had augmented the efficacy of adjuvant radiotherapy (HR = 0.18, 95% CI: 0.04-0.63). Conclusion: Overexpression of HMGA2 is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC. Therefore, HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator for better response of radiotherapy.

UR - http://www.scopus.com/inward/record.url?scp=79954578408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954578408&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-10-2542

DO - 10.1158/1078-0432.CCR-10-2542

M3 - Article

C2 - 21252160

AN - SCOPUS:79954578408

VL - 17

SP - 2570

EP - 2580

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 8

ER -