Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma

Sung Wei Lee, Ching Yih Lin, Yu Feng Tian, Ding Ping Sun, Li Ching Lin, Li Tzong Chen, Chung Hsi Hsing, Chiang Ting Huang, Han Ping Hsu, Hsuan Ying Huang, Li Ching Wu, Chien Feng Li, Yow Ling Shiue

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8 引文 斯高帕斯(Scopus)

摘要

Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p = 0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p 

原文英語
頁(從 - 到)206-214
頁數9
期刊APMIS
122
發行號3
DOIs
出版狀態已發佈 - 三月 2014
對外發佈

ASJC Scopus subject areas

  • 病理學與法醫學
  • 微生物學(醫學)
  • 免疫學和過敏

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